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Major Depressive Disorder clinical trials in Orange, CA

13 studies for Major Depressive Disorder are looking for participants at sites in and around Orange (within about 30 miles). Open a study to see who can join and how to contact the study team.

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A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

RecruitingPhase 3
  • NRC Research Institute, Orange
Ages 18 to 74 · All sexes · Updated Oct 1, 2026 · NCT07573176

A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 2
  • Nrc Research Institute, Orange
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07621237

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

RecruitingPhase 3
  • ATP Clinical Research, Orange
  • NRC Research Institute, Orange
Ages 18 to 85 · All sexes · Updated Sep 25, 2026 · NCT06793397

Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder

RecruitingPhase 3
  • Vanda Investigational Site, Orange
Ages 18 to 65 · All sexes · Updated Sep 24, 2026 · NCT06830044

ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

RecruitingPhase 2
  • PNS Clinical Research LLC dba ATP Clinical Research, Orange
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT07284667

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

RecruitingPhase 3
  • ATP Clinical Research Orange County, Orange
Ages 18 to 74 · All sexes · Updated Aug 10, 2026 · NCT07592689

A Study of Brenipatide in Adult Participants With Major Depressive Disorder

RecruitingPhase 3
  • ATP Clinical Research, Orange
Ages 18 to 75 · All sexes · Updated Aug 6, 2026 · NCT07412756

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

RecruitingPhase 3
  • Atp Clinical Research, Orange
  • Nrc Research Institute, Orange
Ages 18 to 74 · All sexes · Updated Aug 3, 2026 · NCT06775379

A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Orange
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT07196501

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Orange
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401

Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

RecruitingPhase 2
  • Autobahn Site #152, Orange
Ages 18 to 65 · All sexes · Updated Jan 20, 2026 · NCT06633016

Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Orange
Ages 18 and older · All sexes · Updated Oct 29, 2025 · NCT06786624

Major Depressive Disorder trials in other cities

Other studies in Orange

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.