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Depression clinical trials in New Haven, CT

9 studies for Depression are looking for participants at sites in and around New Haven (within about 30 miles). Open a study to see who can join and how to contact the study team.

The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease

RecruitingPhase 2
  • Yale University, New Haven
Ages 40 to 80 · All sexes · Updated Sep 28, 2026 · NCT07610369

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

RecruitingPhase 3
  • Yale School of Medicine - Yale Program for Psychedelic Science, New Haven
Ages 18 to 85 · All sexes · Updated Sep 25, 2026 · NCT06793397

PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study

RecruitingPhase 3
  • Yale School of Medicine, New Haven
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06713616

A Study of Brenipatide in Adult Participants With Major Depressive Disorder

RecruitingPhase 3
  • Yale University School of Medicine, New Haven
Ages 18 to 75 · All sexes · Updated Aug 6, 2026 · NCT07412756

Study of the Safety, Tolerability, Electrophysiological Effects and Efficacy of DMT in Humans

RecruitingPhase 1Healthy volunteers welcome
  • Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine,, West Haven · 3 mi away
Ages 21 to 65 · All sexes · Updated Jun 16, 2026 · NCT06671977

Assessing the Effectiveness of Digital Wellness Modules on Perceived Quality of Life

RecruitingHealthy volunteers welcome
  • Yale University, New Haven
Ages 18 to 65 · All sexes · Updated May 29, 2026 · NCT05810259

The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects

RecruitingPhase 2
  • VA Connecticut Healthcare System, West Haven · 3 mi away
Ages 21 to 65 · All sexes · Updated May 6, 2026 · NCT05786066

Stress and Pain in People Living With HIV

RecruitingHealthy volunteers welcome
  • The Yale Stress Center, New Haven
Ages 18 to 68 · All sexes · Updated Apr 27, 2026 · NCT06784908

Open-Label Psilocybin Study in Transdiagnostic Population

RecruitingPhase 1Healthy volunteers welcome
  • Connecticut Mental Health Center - Yale School of Medicine, New Haven
Ages 18 and older · All sexes · Updated Mar 11, 2026 · NCT06442423

About Depression

Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.

More about Depression on MedlinePlus

Depression trials in other cities

Other studies in New Haven

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.