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Sickle Cell Disease clinical trials in Philadelphia, PA
15 studies for Sickle Cell Disease are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.
Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →
A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)
RecruitingPhase 3
- Thomas Jefferson University Me, Philadelphia
A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
RecruitingPhase 3
- Children's Hosptl Philadelphia, Philadelphia
- St Christopher Hosp for Child, Philadelphia
- Nemours/AI duPont Hosp-Chld, Wilmington · 25 mi away
A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease
RecruitingPhase 1/2Healthy volunteers welcome
- Childrens Hospital Of Philadelphia, Philadelphia
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
RecruitingPhase 1/2Healthy volunteers welcome
- Local Institution - 0029, Philadelphia
- Thomas Jefferson University - Medicine/GI and Hepatology, Philadelphia
ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders
RecruitingObservational study
- Children's Hospital of Philadelphia, Philadelphia
- Penn Comprehensive Hemophilia and Thrombophilia Program/Hospital of the University of Pennsylvania, Philadelphia
- St. Christopher's Hospital for Children, Philadelphia
- and 1 more
Empowering Adolescents and Young Adults With Sickle Cell Disease as Partners in Treatment Decision Making (EMPOWER-AYA)
Recruiting
- Nemours Children's Hospital, Delaware, Wilmington · 25 mi away
Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease
RecruitingObservational study
- Children's Hospital of Philadelphia (MRD-HCT), Philadelphia
- Nemours Children's Hospital, Delaware (MRD-HCT), Wilmington · 25 mi away
Ruxolitinib-Enhanced Haplo HCT for Children and Young Adults With Sickle Cell Disease
RecruitingPhase 1/2
- Children's Hospital of Philadelphia, Philadelphia
Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders
RecruitingPhase 1/2
- Nemours Children's Health, Wilmington · 25 mi away
Clinical and Biomarker Effects of Depot Medroxyprogesterone Acetate in Females With Sickle Cell Disease
RecruitingPhase 4
- Children's Hospital of Philadelphia, Philadelphia
A Socio-ecological Approach for Improving Self-management in Adolescents With SCD
Recruiting
- Children's Hospital of Philadelphia, Philadelphia
- Nemours Children's Health, Wilmington · 25 mi away
Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial
RecruitingPhase 2
- Children's Hospital of Philadelphia, Philadelphia
- Thomas Jefferson University Hospital, Philadelphia
Stress Management and Mindfulness Intervention for Patients With Sickle Cell Disease
Recruiting
- University of Pennsylvania, Philadelphia
A Long-term Follow-up Study in Patients Who Received BEAM-101
RecruitingObservational study
- Children's Hospital of Philadelphia, Philadelphia
Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease
RecruitingObservational study
- University of Pennsylvania, Philadelphia
About Sickle Cell Disease
Sickle cell disease is a group of inherited disorders that affect your red blood cells. It can cause pain, anemia, and other problems. Learn about treatments.
More about Sickle Cell Disease on MedlinePlus
Sickle Cell Disease trials in other cities
- Atlanta, GA22 studies
- Washington, DC20 studies
- Chicago, IL18 studies
- Memphis, TN18 studies
- Birmingham, AL14 studies
- New York City, NY13 studies
- St. Louis, MO12 studies
- Boston, MA10 studies
- Durham, NC10 studies
- Houston, TX10 studies
- Cincinnati, OH10 studies
- Greenville, NC9 studies
Other studies in Philadelphia
- Cancer (all types)59 studies
- Breast Cancer56 studies
- Non-Small Cell Lung Cancer51 studies
- Metastatic Cancer46 studies
- Prostate Cancer44 studies
- Colorectal Cancer44 studies
- Ovarian Cancer44 studies
- Lung Cancer36 studies
- Acute Myeloid Leukemia34 studies
- Heart Failure31 studies
- Endometrial Cancer28 studies
- Depression26 studies
From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.