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Major Depressive Disorder clinical trials in Boston, MA
31 studies for Major Depressive Disorder are looking for participants at sites in and around Boston (within about 30 miles). Open a study to see who can join and how to contact the study team.
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A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
RecruitingPhase 3
- Adams Clinical Boston, Boston
A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
RecruitingPhase 3
- Adams Clinical Boston, Boston
A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder
RecruitingPhase 3
- Boston Childrens Hospital, Boston
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
RecruitingPhase 3
- Adams Clinical Boston, Boston
Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder
RecruitingPhase 3
- Vanda Investigational Site, Boston
Accelerated TMS for Perinatal Depression
Recruiting
- Brigham and Women's Hospital, Boston
A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
RecruitingPhase 2
- Seaport Investigator Site, Boston
A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)
RecruitingPhase 3
- Adams Clinical Boston, Boston
A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
RecruitingPhase 2
- Draig Clinical Site, Boston
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
Recruiting
- Massachusetts General Hospital, Boston
- Beth Israel Deaconess Medical Center, Boston
Home-Based tDCS Treatment Of Major Depressive Disorder
Recruiting
- Curavit Clinical Research (virtual study site), Boston
The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disorder
RecruitingPhase 3
- Athinoula A. Martinos Center for Biomedical Imaging, Charlestown · 1 mi away
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
RecruitingPhase 3
- Adams Clinical Boston, Boston
- Adams Clinical Watertown, Boston
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
RecruitingPhase 3
- Adams Clinical Boston, Boston
A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder
RecruitingPhase 3
- Boston Clinical Trials Llc, Boston
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, Boston
Triage Survey for Psychiatry Research Eligibility
RecruitingObservational study
- Adams Clinical, Boston, Boston
Mechanisms Of Orbitofrontal Stimulation in Depression
Recruiting
- Beth Israel Deaconess Medical Center, Boston
Mindfulness-Based fMRI Neurofeedback for Depression
Recruiting
- Northeastern University, Boston
REVEAL Study - Diagnostic Testing for PTSD Using the Senseye Diagnostic Tool
RecruitingPhase 3Healthy volunteers welcome
- Lindus Health (Virtual Study Site), Boston
Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services
RecruitingObservational study
- Beth Israel Deaconess Medical Center, Boston
Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33
Recruiting
- Harvard Medical School, Boston
Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)
RecruitingPhase 2
- Autobahn Site #137, Boston
Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression
RecruitingPhase 4
- Massachusetts General Hospital, Boston
Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, Boston
Targeting Specific Brain Networks to Treat Specific Symptoms in Depression
RecruitingHealthy volunteers welcome
- Massachusetts General Hospital, Boston
Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV
RecruitingPhase 2
- Massachusetts General Hospital, Boston
Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
RecruitingHealthy volunteers welcome
- Massachusetts General Hospital, Boston
Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab
RecruitingPhase 2
- Massachusetts General Hospital, Boston
A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
RecruitingPhase 4
- Clinical Research Site, Boston
Peripheral Neuroimmune Mechanisms of Hyperthermia
Recruiting
- Massachusetts General Hospital Depression Clinical & Research Program, Boston
Major Depressive Disorder trials in other cities
- New York City, NY37 studies
- Atlanta, GA25 studies
- Philadelphia, PA23 studies
- Orlando, FL19 studies
- Miami, FL18 studies
- Chicago, IL17 studies
- Tampa, FL17 studies
- Houston, TX16 studies
- San Diego, CA16 studies
- Little Rock, AR14 studies
- Orange, CA13 studies
- Austin, TX13 studies
Other studies in Boston
- Breast Cancer111 studies
- Non-Small Cell Lung Cancer90 studies
- Cancer (all types)86 studies
- Colorectal Cancer63 studies
- Metastatic Cancer63 studies
- Lung Cancer62 studies
- Ovarian Cancer61 studies
- Prostate Cancer59 studies
- Depression52 studies
- Endometrial Cancer50 studies
- Heart Failure44 studies
- Acute Myeloid Leukemia44 studies
From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.