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Colorectal Cancer clinical trials in Cincinnati, OH

21 studies for Colorectal Cancer are looking for participants at sites in and around Cincinnati (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Good Samaritan Hospital - Cincinnati, Cincinnati
  • Oncology Hematology Care Inc-Kenwood, Cincinnati
  • Bethesda North Hospital, Cincinnati
  • and 3 more
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

Family Communications After Genetic Testing

RecruitingHealthy volunteers welcome
  • University of Cincinnati Cancer Center-UC Medical Center, Cincinnati
  • Good Samaritan Hospital - Cincinnati, Cincinnati
  • Oncology Hematology Care Inc-Kenwood, Cincinnati
  • and 4 more
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07143487

Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable Cancers

RecruitingPhase 1
  • University of Cincinnati Cancer Center-UC Medical Center, Cincinnati
  • University of Cincinnati Cancer Center-West Chester, West Chester · 15 mi away
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT05803382

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

RecruitingPhase 3
  • Oncology Hematology Care - Eastgate, Cincinnati
  • Oncology Hematology Care Clinical Trials, LLC, Fairfield · 15 mi away
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07222800

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

RecruitingPhase 2
  • Research Site, Cincinnati
Ages 18 to 130 · All sexes · Updated Sep 23, 2026 · NCT05489211

Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

RecruitingPhase 1/2
  • University of Cincinnati Medical Center, Cincinnati
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06445062

A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer

RecruitingPhase 3
  • University of Cincinnati Cancer Institute, Cincinnati
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07284849

Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer

RecruitingPhase 3
  • Clinical Study Site, Cincinnati
  • Clinical Study Site, Cincinnati
  • Clinical Study Site, Edgewood · 8 mi away
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT07228832

A Phase 1 Study Evaluating DISP-10 in Participants With Advanced Gastrointestinal Cancers

RecruitingPhase 1
  • University of Cincinnati Cancer Center, Cincinnati
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT07544589

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

RecruitingPhase 1/2
  • Cincinnati Children's Hospital Medical Center, Cincinnati
12 Months – 30 Years · All sexes · Updated Aug 25, 2026 · NCT04851119

MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors

RecruitingPhase 1
  • University of Cincinnati (UC) - Cancer Institute, Cincinnati
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06586515

Testing the Addition of an Anti-Cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (5-Fluorouracil) for Metastatic, Refractory Colorectal Cancer

RecruitingPhase 1
  • University of Cincinnati Cancer Center-UC Medical Center, Cincinnati
  • University of Cincinnati Cancer Center-West Chester, West Chester · 15 mi away
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT06654037

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Oncology Hematology Care Primary, Cincinnati
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT04657068

Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions

RecruitingPhase 1/2
  • University of Cincinnati Cancer Center, Cincinnati
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT03947385

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

RecruitingPhase 1
  • The Christ Hospital, Cincinnati
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT06040541

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

RecruitingPhase 1/2
  • Christ Hospital Cancer Center, Cincinnati
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT05379985

Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors

RecruitingPhase 3Healthy volunteers welcome
  • Good Samaritan Hospital - Cincinnati, Cincinnati
  • Bethesda North Hospital, Cincinnati
  • TriHealth Cancer Institute-Westside, Cincinnati
  • and 1 more
Ages 18 and older · All sexes · Updated Mar 31, 2026 · NCT07018869

64Cu-LNTH-1363S in Patients With Sarcoma or Gastrointestinal Tract Cancer

RecruitingPhase 1/2
  • Cincinnati Children's Hospital Medical Center, Cincinnati
Ages 15 and older · All sexes · Updated Aug 12, 2025 · NCT06298916

Tempus CRC Surveillance Study: A ctDNA Biomarker Profiling Study of Patients With CRC Using NGS Assays

RecruitingObservational study
  • TriHealth Cancer Institute, Cincinnati
Ages 18 and older · All sexes · Updated May 6, 2025 · NCT05234177

About Colorectal Cancer

Colorectal cancer starts in the colon or rectum. It may not cause symptoms at first. Screening tests can help find it early, when treatment is most effective.

More about Colorectal Cancer on MedlinePlus

Colorectal Cancer trials in other cities

Other studies in Cincinnati

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.