🔎 Trials Near Me

Home › Major Depressive Disorder › Massachusetts › Boston

Major Depressive Disorder clinical trials in Boston, MA

31 studies for Major Depressive Disorder are looking for participants at sites in and around Boston (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder

RecruitingPhase 3
  • Adams Clinical Boston, Boston
Ages 18 to 75 · All sexes · Updated Oct 1, 2026 · NCT07775300

A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

RecruitingPhase 3
  • Adams Clinical Boston, Boston
Ages 18 to 74 · All sexes · Updated Oct 1, 2026 · NCT07573176

A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder

RecruitingPhase 3
  • Boston Childrens Hospital, Boston
Ages 12 to 17 · All sexes · Updated Sep 25, 2026 · NCT07227454

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

RecruitingPhase 3
  • Adams Clinical Boston, Boston
Ages 18 to 85 · All sexes · Updated Sep 25, 2026 · NCT06793397

Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder

RecruitingPhase 3
  • Vanda Investigational Site, Boston
Ages 18 to 65 · All sexes · Updated Sep 24, 2026 · NCT06830044

Accelerated TMS for Perinatal Depression

Recruiting
  • Brigham and Women's Hospital, Boston
Ages 18 to 55 · Women · Updated Sep 18, 2026 · NCT06968390

A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

RecruitingPhase 2
  • Seaport Investigator Site, Boston
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT07065240

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)

RecruitingPhase 3
  • Adams Clinical Boston, Boston
Ages 18 to 74 · All sexes · Updated Sep 8, 2026 · NCT07076407

A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

RecruitingPhase 2
  • Draig Clinical Site, Boston
Ages 18 to 75 · All sexes · Updated Sep 2, 2026 · NCT07610473

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

Recruiting
  • Massachusetts General Hospital, Boston
  • Beth Israel Deaconess Medical Center, Boston
Ages 22 to 70 · All sexes · Updated Aug 28, 2026 · NCT06423430

Home-Based tDCS Treatment Of Major Depressive Disorder

Recruiting
  • Curavit Clinical Research (virtual study site), Boston
Ages 22 to 70 · All sexes · Updated Aug 14, 2026 · NCT06976697

The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disorder

RecruitingPhase 3
  • Athinoula A. Martinos Center for Biomedical Imaging, Charlestown · 1 mi away
Ages 18 to 55 · All sexes · Updated Aug 13, 2026 · NCT06247839

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

RecruitingPhase 3
  • Adams Clinical Boston, Boston
  • Adams Clinical Watertown, Boston
Ages 18 to 74 · All sexes · Updated Aug 10, 2026 · NCT07592689

A Study of Brenipatide in Adult Participants With Major Depressive Disorder

RecruitingPhase 3
  • Adams Clinical Boston, Boston
Ages 18 to 75 · All sexes · Updated Aug 6, 2026 · NCT07412756

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

RecruitingPhase 3
  • Boston Clinical Trials Llc, Boston
Ages 18 to 74 · All sexes · Updated Aug 3, 2026 · NCT06775379

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Boston
Ages 18 and older · All sexes · Updated Jul 24, 2026 · NCT06966401

Triage Survey for Psychiatry Research Eligibility

RecruitingObservational study
  • Adams Clinical, Boston, Boston
Ages 18 and older · All sexes · Updated May 20, 2026 · NCT05800925

Mechanisms Of Orbitofrontal Stimulation in Depression

Recruiting
  • Beth Israel Deaconess Medical Center, Boston
Ages 18 to 65 · All sexes · Updated May 14, 2026 · NCT07230990

Mindfulness-Based fMRI Neurofeedback for Depression

Recruiting
  • Northeastern University, Boston
Ages 13 to 18 · All sexes · Updated Apr 29, 2026 · NCT05617495

REVEAL Study - Diagnostic Testing for PTSD Using the Senseye Diagnostic Tool

RecruitingPhase 3Healthy volunteers welcome
  • Lindus Health (Virtual Study Site), Boston
Ages 18 and older · All sexes · Updated Apr 29, 2026 · NCT07280065

Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services

RecruitingObservational study
  • Beth Israel Deaconess Medical Center, Boston
Ages 18 to 40 · All sexes · Updated Mar 10, 2026 · NCT06740383

Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33

Recruiting
  • Harvard Medical School, Boston
Ages 18 to 65 · All sexes · Updated Feb 5, 2026 · NCT05573074

Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

RecruitingPhase 2
  • Autobahn Site #137, Boston
Ages 18 to 65 · All sexes · Updated Jan 20, 2026 · NCT06633016

Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression

RecruitingPhase 4
  • Massachusetts General Hospital, Boston
Ages 18 to 70 · All sexes · Updated Dec 12, 2025 · NCT05450432

Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 3
  • Neurocrine Clinical Site, Boston
Ages 18 and older · All sexes · Updated Oct 29, 2025 · NCT06786624

Targeting Specific Brain Networks to Treat Specific Symptoms in Depression

RecruitingHealthy volunteers welcome
  • Massachusetts General Hospital, Boston
Ages 18 to 65 · All sexes · Updated Sep 29, 2025 · NCT05523817

Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
Ages 18 to 85 · All sexes · Updated Sep 12, 2025 · NCT05570812

Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

RecruitingHealthy volunteers welcome
  • Massachusetts General Hospital, Boston
Ages 18 to 65 · All sexes · Updated Sep 10, 2025 · NCT04296604

Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab

RecruitingPhase 2
  • Massachusetts General Hospital, Boston
Ages 25 to 50 · All sexes · Updated May 7, 2025 · NCT06136546

A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

RecruitingPhase 4
  • Clinical Research Site, Boston
Ages 18 to 65 · All sexes · Updated Jan 23, 2025 · NCT06223880

Peripheral Neuroimmune Mechanisms of Hyperthermia

Recruiting
  • Massachusetts General Hospital Depression Clinical & Research Program, Boston
Ages 18 to 65 · All sexes · Updated Mar 10, 2023 · NCT05366270

Major Depressive Disorder trials in other cities

Other studies in Boston

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.