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Major Depressive Disorder clinical trials in Philadelphia, PA
23 studies for Major Depressive Disorder are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.
Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
RecruitingPhase 3
- Adams Clinical Philadelphia, Philadelphia
- Flourish Research Philadelphia, Philadelphia
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
RecruitingPhase 3
- Adams Clinical Philadelphia, Philadelphia
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
RecruitingPhase 3
- Penn Medicine: University of Pennsylvania Health System, Philadelphia
- Suburban Research Associates, West Chester · 24 mi away
A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
RecruitingPhase 3
- Adams Clinical Philadelphia, Philadelphia
- Penn Medicine: University of Pennsylvania Health System, Philadelphia
- Suburban Research Associates, West Chester · 24 mi away
Precision Depression Adalimumab Trial
RecruitingPhase 2
- University of Pennsylvania, Philadelphia
Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder
RecruitingPhase 3
- University of Pennsylvania - Perelman School of Medicine, Philadelphia
Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
RecruitingPhase 3
- University of Pennsylvania, Philadelphia
Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine
RecruitingEarly phase 1
- University of Pennsylvania, Philadelphia
Decoding and Modulating Affective Brain States
RecruitingMentions payment for participants
- University of Pennsylvania, Philadelphia
A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
RecruitingPhase 2
- Draig Clinical Site, Media · 12 mi away
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
Recruiting
- Pennsylvania Hospital, Philadelphia
A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
RecruitingPhase 2
- Draig Clinical Site, Media · 12 mi away
Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression
RecruitingPhase 3
- Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, Philadelphia
NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, Philadelphia
A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder
RecruitingPhase 3
- Adams Clinical - Philadelphia, Philadelphia
A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
RecruitingPhase 2
- Adams Clinical, Philadelphia
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, Philadelphia
A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, Philadelphia
Triage Survey for Psychiatry Research Eligibility
RecruitingObservational study
- Adams Clinical, Philadelphia, Philadelphia
A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
RecruitingPhase 2
- University of Pennsylvania, Philadelphia
Taking Action for College Students
Recruiting
- Temple University, Philadelphia
Neurofeedback to Treat Depression - 2
Recruiting
- Center for Neuromodulation in Depression and Stress, Philadelphia
Study of ALTO-300 in MDD
RecruitingPhase 2
- Site 350, Media · 12 mi away
Major Depressive Disorder trials in other cities
- New York City, NY36 studies
- Boston, MA31 studies
- Atlanta, GA25 studies
- Orlando, FL19 studies
- Miami, FL18 studies
- Chicago, IL17 studies
- Tampa, FL17 studies
- San Diego, CA16 studies
- Houston, TX16 studies
- Little Rock, AR14 studies
- Austin, TX13 studies
- Las Vegas, NV13 studies
Other studies in Philadelphia
- Cancer (all types)59 studies
- Breast Cancer56 studies
- Non-Small Cell Lung Cancer51 studies
- Metastatic Cancer46 studies
- Prostate Cancer44 studies
- Colorectal Cancer44 studies
- Ovarian Cancer44 studies
- Lung Cancer36 studies
- Acute Myeloid Leukemia34 studies
- Heart Failure31 studies
- Endometrial Cancer28 studies
- Depression26 studies
From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.