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Sickle Cell Disease clinical trials in Philadelphia, PA

15 studies for Sickle Cell Disease are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

RecruitingPhase 3
  • Children's Hosptl Philadelphia, Philadelphia
  • St Christopher Hosp for Child, Philadelphia
  • Nemours/AI duPont Hosp-Chld, Wilmington · 25 mi away
Ages 12 and older · All sexes · Updated Sep 17, 2026 · NCT06612268

A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease

RecruitingPhase 1/2Healthy volunteers welcome
  • Childrens Hospital Of Philadelphia, Philadelphia
Ages 12 to 55 · All sexes · Updated Sep 9, 2026 · NCT06546670

A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease

RecruitingPhase 1/2Healthy volunteers welcome
  • Local Institution - 0029, Philadelphia
  • Thomas Jefferson University - Medicine/GI and Hepatology, Philadelphia
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT06481306

ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders

RecruitingObservational study
  • Children's Hospital of Philadelphia, Philadelphia
  • Penn Comprehensive Hemophilia and Thrombophilia Program/Hospital of the University of Pennsylvania, Philadelphia
  • St. Christopher's Hospital for Children, Philadelphia
  • and 1 more
All ages · All sexes · Updated Aug 17, 2026 · NCT04398628

Empowering Adolescents and Young Adults With Sickle Cell Disease as Partners in Treatment Decision Making (EMPOWER-AYA)

Recruiting
  • Nemours Children's Hospital, Delaware, Wilmington · 25 mi away
Ages 15 and older · All sexes · Updated Jun 16, 2026 · NCT05383911

Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease

RecruitingObservational study
  • Children's Hospital of Philadelphia (MRD-HCT), Philadelphia
  • Nemours Children's Hospital, Delaware (MRD-HCT), Wilmington · 25 mi away
Ages 3 to 20 · All sexes · Updated Jun 4, 2026 · NCT06941389

Ruxolitinib-Enhanced Haplo HCT for Children and Young Adults With Sickle Cell Disease

RecruitingPhase 1/2
  • Children's Hospital of Philadelphia, Philadelphia
Ages 12 to 45 · All sexes · Updated Jun 4, 2026 · NCT07252050

Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders

RecruitingPhase 1/2
  • Nemours Children's Health, Wilmington · 25 mi away
1 Day – 21 Years · All sexes · Updated May 29, 2026 · NCT03128996

Clinical and Biomarker Effects of Depot Medroxyprogesterone Acetate in Females With Sickle Cell Disease

RecruitingPhase 4
  • Children's Hospital of Philadelphia, Philadelphia
Ages 18 to 50 · Women · Updated May 28, 2026 · NCT06665997

A Socio-ecological Approach for Improving Self-management in Adolescents With SCD

Recruiting
  • Children's Hospital of Philadelphia, Philadelphia
  • Nemours Children's Health, Wilmington · 25 mi away
Ages 13 to 21 · All sexes · Updated May 11, 2026 · NCT06290401

Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial

RecruitingPhase 2
  • Children's Hospital of Philadelphia, Philadelphia
  • Thomas Jefferson University Hospital, Philadelphia
Ages 15 to 40 · All sexes · Updated Mar 13, 2026 · NCT06260891

Stress Management and Mindfulness Intervention for Patients With Sickle Cell Disease

Recruiting
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Feb 27, 2026 · NCT07316478

A Long-term Follow-up Study in Patients Who Received BEAM-101

RecruitingObservational study
  • Children's Hospital of Philadelphia, Philadelphia
Ages 14 to 37 · All sexes · Updated Jan 28, 2026 · NCT07373639

Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease

RecruitingObservational study
  • University of Pennsylvania, Philadelphia
Ages 18 and older · All sexes · Updated Jun 22, 2025 · NCT06385886

About Sickle Cell Disease

Sickle cell disease is a group of inherited disorders that affect your red blood cells. It can cause pain, anemia, and other problems. Learn about treatments.

More about Sickle Cell Disease on MedlinePlus

Sickle Cell Disease trials in other cities

Other studies in Philadelphia

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.