🔎 Trials Near Me

Home › Colorectal Cancer › Florida › Orlando

Colorectal Cancer clinical trials in Orlando, FL

19 studies for Colorectal Cancer are looking for participants at sites in and around Orlando (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • Advent Health, Orlando
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors

RecruitingPhase 1
  • Exelixis Clinical Site #48, Celebration · 17 mi away
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05176483

A Study of GSK5764227 in Combination With Standard of Care (SoC) or Other Agents in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • GSK Investigational Site, Reunion · 23 mi away
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07277270

A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

RecruitingPhase 3
  • AdventHealth Cancer Institute, Orlando
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06750094

A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

RecruitingPhase 3
  • AdventHealth Medical Group Oncology and Hematology at Orlando, Orlando
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06662786

A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer

RecruitingPhase 3
  • Advent Health, Orlando
  • Orlando Health Cancer Institute Downtown Orlando, Orlando
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07284849

Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer

RecruitingPhase 3
  • Clinical Study Site, Orlando
  • Clinical Study Site, Orlando
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT07228832

A Randomized Phase 2 Trial of Fruquintinib and TAS-102 as Compared to Fruquintinib in Patients With Refractory Advanced/Metastatic Colorectal Cancer

RecruitingPhase 2
  • Orlando Health Cancer Institute, Orlando
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT06992258

A Clinical Trial to Test if the Investigational Drug BNT329 is Safe and Potentially Beneficial for People With Advanced Solid Tumors Known to Express the Tumor Marker CA19-9

RecruitingPhase 1/2
  • Florida Cancer Specialists, Orlando
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT07186842

MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors

RecruitingPhase 1
  • Florida Cancer Specialists - Lake Nona - Sarah Cannon Research Institute, Orlando
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06586515

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • AdventHealth Celebration, Celebration · 17 mi away
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT05592626

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Sarah Cannon Research Institute (Lake Nona), Orlando
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT03526835

A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors

RecruitingPhase 1
  • Florida Cancer Specialists, Orlando
  • Sarah Cannon Research Institute at Florida Cancer Specialists, Orlando
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT06131840

Initial Safety of SFM Plus OTOLoc for Creating Side-to-side or End-to-side Colorectal Anastomoses

Recruiting
  • Orlando Health, Orlando
Ages 22 and older · All sexes · Updated Jul 6, 2026 · NCT07276529

A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations

RecruitingPhase 1
  • Research Site, Orlando
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06835569

KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors

RecruitingPhase 1
  • AdventHealth Celebration, Celebration · 17 mi away
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT06026410

Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Florida Cancer Specialists-Lake Nona, Orlando
Ages 18 and older · All sexes · Updated Feb 18, 2026 · NCT07030257

About Colorectal Cancer

Colorectal cancer starts in the colon or rectum. It may not cause symptoms at first. Screening tests can help find it early, when treatment is most effective.

More about Colorectal Cancer on MedlinePlus

Colorectal Cancer trials in other cities

Other studies in Orlando

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.