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Heart Failure clinical trials in Pittsburgh, PA

19 studies for Heart Failure are looking for participants at sites in and around Pittsburgh (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

RecruitingPhase 3
  • University of Pittsburgh Medical Center, Pittsburgh
Ages 18 to 99 · All sexes · Updated Sep 16, 2026 · NCT07037459

A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

RecruitingPhase 3
  • Pittsburg, PA Investigative Site 1044, Pittsburgh
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06008197

A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF)

RecruitingPhase 2
  • Local Institution - 124, Pittsburgh
Ages 30 to 84 · All sexes · Updated Aug 31, 2026 · NCT07795814

Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

RecruitingPhase 2/3
  • Children's Hospital of Pittsburgh ( Site 0010), Pittsburgh
29 Days – 17 Years · All sexes · Updated Aug 28, 2026 · NCT05714085

Optimal Pediatric Heart Transplant Immunosuppression With MicroRNAs

RecruitingObservational study
  • University of Pittsburgh, Pittsburgh
Up to age 18 · All sexes · Updated Aug 25, 2026 · NCT06532890

Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

RecruitingObservational study
  • Pittsburgh, Pittsburgh
All ages · All sexes · Updated Aug 20, 2026 · NCT00271180

LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2

RecruitingPhase 3
  • Tenax Investigational Site, Pittsburgh
Ages 18 to 85 · All sexes · Updated Aug 19, 2026 · NCT07288398

Assessment of CCM in HF With Higher Ejection Fraction

Recruiting
  • Allegheny General Hospital, Pittsburgh
  • University of Pittsburgh Medical Center, Pittsburgh
  • Bryn Mawr Medical Specialists Association, Bryn Mawr · 11 mi away
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT05064709

A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction

RecruitingPhase 3
  • UPMC Children's Hospital of Pittsburgh - Cardiology, Pittsburgh
Up to age 18 · All sexes · Updated Jun 29, 2026 · NCT07192952

PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

Recruiting
  • UPMC, Pittsburgh
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05934487

Quantifying New Heart Muscle Cells

Recruiting
  • Upmc Children'S Hospital of Pittsburgh, Pittsburgh
30 Days – 1 Year · All sexes · Updated Jun 15, 2026 · NCT06587165

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

Recruiting
  • Allegheny General Hospital, Pittsburgh
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06526195

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

Recruiting
  • Allegheny Health Network, Pittsburgh
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT03142152

POCUS-Guided Diuresis for Decompensated Heart Failure

Recruiting
  • UPMC East, Pittsburgh
  • University of Pittsburgh Medical Center, Pittsburgh
  • UPMC Presbyterian, Pittsburgh
  • and 2 more
Ages 18 and older · All sexes · Updated Feb 17, 2026 · NCT06921603

Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial

RecruitingPhase 2/3
  • VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh
Ages 18 and older · All sexes · Updated Dec 15, 2025 · NCT04982419

Left vs Left Randomized Clinical Trial

Recruiting
  • Allegheny-Singer Research Institute, Pittsburgh
  • University of Pittsburg, Pittsburgh
Ages 18 and older · All sexes · Updated Oct 2, 2025 · NCT05650658

Cardiogenic Shock Working Group Registry

RecruitingObservational study
  • Allegheny General Hospital, Pittsburgh
  • University Of Pittsburgh Medical Center, Pittsburgh
Ages 18 and older · All sexes · Updated Jun 6, 2025 · NCT04682483

About Heart Failure

Heart failure, or congestive heart failure (CHF), means the heart can't pump enough blood. Learn about the signs, symptoms, and causes.

More about Heart Failure on MedlinePlus

Heart Failure trials in other cities

Other studies in Pittsburgh

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.