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Heart Failure clinical trials in Charleston, SC

18 studies for Heart Failure are looking for participants at sites in and around Charleston (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

ELEVATE-HFpEF Clinical Study

Recruiting
  • Medical University of South Carolina (MUSC), Charleston
Ages 40 and older · All sexes · Updated Oct 2, 2026 · NCT06678841

Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function

RecruitingPhase 3
  • Research Site, Charleston
  • Research Site, Charleston
Ages 18 to 130 · All sexes · Updated Oct 2, 2026 · NCT06307652

A Phase 1 AAV Gene Therapy Trial Evaluating Safety and Preliminary Efficacy of RP-A701 in Subjects With BAG3 Dilated Cardiomyopathy

RecruitingPhase 1
  • Medical University of South Carolina, Charleston
Ages 18 to 65 · All sexes · Updated Oct 1, 2026 · NCT07137338

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

RecruitingPhase 3
  • Medical University of South Carolina - Gazes Research Institute, Charleston
Ages 18 to 85 · All sexes · Updated Sep 24, 2026 · NCT06736574

Evaluation of Liver Stiffness Performance, by FibroScan®, to Detect Elevated Central Venous Pressure (CVP)

Recruiting
  • Medical University of South Carolina, Charleston
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07222813

Alleviant ALLAY-HFrEF Study

Recruiting
  • Roper St. Francis Healthcare, Charleston
  • Medical University of South Carolina, Charleston
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT06812533

A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

RecruitingPhase 3
  • Charleston, SC Investigative Site 10056, Charleston
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06008197

The WiSE®-UP Study (The WiSE System Utilization & Performance Study)

RecruitingObservational study
  • MUSC, Charleston
Ages 22 and older · All sexes · Updated Sep 10, 2026 · NCT07098858

Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

Recruiting
  • Medical University of South Carolina, Charleston
Ages 18 to 100 · All sexes · Updated Sep 9, 2026 · NCT06310031

A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF)

RecruitingPhase 2
  • Local Institution - 142, Charleston
Ages 30 to 84 · All sexes · Updated Aug 31, 2026 · NCT07795814

LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2

RecruitingPhase 3
  • Tenax Investigational Site, Charleston
Ages 18 to 85 · All sexes · Updated Aug 19, 2026 · NCT07288398

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

RecruitingPhase 3
  • Med. Uni. of SC Ashley River T, Charleston
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07567001

Alleviant ALLAY-HF Study

Recruiting
  • Medical University of South Carolina, Charleston
Ages 40 and older · All sexes · Updated Aug 14, 2026 · NCT05685303

OPtimal Adult Heart Transplant Immunosuppression With MicroRNA Levels

RecruitingObservational study
  • Medical University of South Carolina, Charleston
Ages 18 to 99 · All sexes · Updated Aug 11, 2026 · NCT06939751

PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

Recruiting
  • Medical University of South Carolina (MUSC), Charleston
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05934487

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

Recruiting
  • Medical University of South Carolina, Charleston
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06526195

Left vs Left Randomized Clinical Trial

Recruiting
  • Medical University of South Carolina (MUSC), Charleston
Ages 18 and older · All sexes · Updated Oct 2, 2025 · NCT05650658

About Heart Failure

Heart failure, or congestive heart failure (CHF), means the heart can't pump enough blood. Learn about the signs, symptoms, and causes.

More about Heart Failure on MedlinePlus

Heart Failure trials in other cities

Other studies in Charleston

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.