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Sickle Cell Disease clinical trials in Durham, NC

10 studies for Sickle Cell Disease are looking for participants at sites in and around Durham (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)

RecruitingPhase 1
  • Duke University Medical Center, Durham
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07187973

A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia

RecruitingPhase 3
  • Duke University_Durham, Durham
Ages 2 and older · All sexes · Updated Sep 18, 2026 · NCT06609226

A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

RecruitingPhase 3
  • Duke Comprehen Sickle Cell, Durham
  • Duke University Medical Center, Durham
Ages 12 and older · All sexes · Updated Sep 17, 2026 · NCT06612268

A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD

RecruitingPhase 2/3
  • Duke University IDS Pharmacy, Durham
  • Duke University Medical Center, Durham
  • Clinical & Translational Research Center (CTRC), Chapel Hill · 10 mi away
  • and 2 more
Ages 12 and older · All sexes · Updated Aug 18, 2026 · NCT05431088

ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders

RecruitingObservational study
  • Comprehensive Hemophilia Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
All ages · All sexes · Updated Aug 17, 2026 · NCT04398628

Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease

RecruitingObservational study
  • UNC Children's Hospital (MRD HCT), Chapel Hill · 10 mi away
  • UNC Children's Hospital (NT-DMT), Chapel Hill · 10 mi away
Ages 3 to 20 · All sexes · Updated Jun 4, 2026 · NCT06941389

SickleFit Exercise and Nutrition Study

Recruiting
  • Duke University, Durham
Ages 35 and older · All sexes · Updated May 7, 2026 · NCT07442851

Predictors of Pain in Sickle Cell Disease

Recruiting
  • Duke University Medical Center, Durham
Ages 15 to 40 · All sexes · Updated May 5, 2026 · NCT06139510

Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial

RecruitingPhase 2
  • Duke University Medical Center, Durham
Ages 15 to 40 · All sexes · Updated Mar 13, 2026 · NCT06260891

Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain

Recruiting
  • Wake Forest Baptist Hospital, Durham
Ages 16 to 30 · All sexes · Updated Jan 7, 2026 · NCT06374238

About Sickle Cell Disease

Sickle cell disease is a group of inherited disorders that affect your red blood cells. It can cause pain, anemia, and other problems. Learn about treatments.

More about Sickle Cell Disease on MedlinePlus

Sickle Cell Disease trials in other cities

Other studies in Durham

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.