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Depression clinical trials in New York City, NY
45 studies for Depression are looking for participants at sites in and around New York City (within about 30 miles). Open a study to see who can join and how to contact the study team.
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A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
RecruitingPhase 3
- Adams Clinical Harlem, New York
- New York State Psychiatric Institute, New York
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
RecruitingPhase 3
- Adams Clinical Harlem, New York
Heart Rate Variability (HRV)-Guided Transcranial Direct Current Stimulation (tDCS)
Recruiting
- NYU Langone Health, New York
A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 2
- Ima Clinical Research - Nyc Midtown, New York
WellPATH-PREVENT: A Mobile Intervention for Middle-Aged and Older Adults Hospitalized for Suicidal Ideation or Attempt
Recruiting
- New York Presbyterian Hospital/Weill Cornell Medicine, New York
RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
RecruitingPhase 2
- NYU Langone Health, New York
Psilocybin as a Novel Therapy for Residual Anhedonia
RecruitingPhase 1
- NYU Langone Health, New York
Pattern Separation in Major Depressive Disorder
RecruitingPhase 1
- New York State Psychiatric Institute (NYSPI), New York
A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
RecruitingPhase 2
- Seaport Investigator Site, New York
A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)
RecruitingPhase 3
- Fieve Clinical Research, Inc., New York
- IMA Clinical Research, New York
A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
RecruitingPhase 2
- Draig Clinical Site, New York
- Draig Clinical Site, New York
A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
RecruitingPhase 2
- Draig Clinical Site, New York
A Digital Intervention for Post-Stroke Depression and Executive Dysfunction
RecruitingPhase 2
- Weill Cornell Medical Center, New York
Improving the Mental Health of Home Health Aides
RecruitingHealthy volunteers welcome
- 1199 SEIU Home Care Industry Education Fund, New York
- Weill Cornell Medicine, New York
Psilocybin-Assisted Therapy for Intergenerational Trauma
RecruitingPhase 2
- The Parsons Research Center for Psychedelic Healing, New York
NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, New York
NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, New York
Mobile Cognitive Behavioral Therapy for Stroke
Recruiting
- Weill Cornell Medicine, New York
E-Mindfulness Approaches for Living After Breast Cancer
RecruitingPhase 3
- Mount Sinai Union Square, New York
- Mount Sinai Chelsea, New York
- Mount Sinai West, New York
- and 1 more
Tele-PROTECT Therapy: Effectiveness, Empowerment, and Implementation
Recruiting
- Weill Cornell Medicine, New York
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 3
- Neurocrine Clinical Site, New York
- Neurocrine Clinical Site, New York
Sleep More, Stress Less: 90-Day Trial of Neuralli Mood
RecruitingHealthy volunteers welcome
- Efforia - Decentralized United States Study, New York
Assessment of Music Experiences in Navigating Depression Part 2
Recruiting
- Mount Sinai Union Square, New York
Home-Based Transcranial Direct Current Stimulation (tDCS) for Depression in Multiple Sclerosis (MS)
RecruitingPhase 2
- NYU Langone Health, New York
Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD)
Recruiting
- NYU Langone Health, New York
Virtual Reality for Pain Management in Burn Patients
Recruiting
- Weill Cornell Medicine, New York
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Recruiting
- Icahn School of Medicine at Mount Sinai, New York
WeCare: A System of Care for Black Youth
RecruitingHealthy volunteers welcome
- Kings County Hospital, New York
tDCS: Sleep to Mood in Depression (S2M-D)
Recruiting
- NYU Langone Health, New York
Personalized Mobile Cognitive Behavioral Therapy Application
Recruiting
- Weill Cornell Medical College, New York
Mobile CBT for Middle Aged and Older Adults
Recruiting
- Weill Cornell Medicine, New York
Harlem Strong Mental Health Coalition
RecruitingHealthy volunteers welcome
- CUNY Graduate School of Public Health and Health Policy, New York
- Harlem Congregation for Community Improvement, New York
Prevention of Psychological Health Problems Via Integrated Operational Support
RecruitingHealthy volunteers welcome
- New York University, New York
A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
RecruitingPhase 2
- The Medical Research Network, LLC, New York
Safe Mothers, Safe Children Initiative
Recruiting
- McSilver Institute for Poverty Policy and Research, New York
Neutralizing Interleukin (IL)-6
RecruitingPhase 2Healthy volunteers welcome
- Icahn School of Medicine at Mount Sinai, New York
Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality
Recruiting
- Weill Cornell Medicine, New York
Readiness and Progress in Emotion Regulation Therapy
Recruiting
- Teachers College, Columbia University, New York
A Patient Activation Approach to Implementing Depression Treatment in Cardiac Patients
Recruiting
- Columbia University Irving Medical Center, New York
A Digitally Assisted Risk Reduction Platform for Youth at High Risk for Suicide
Recruiting
- Columbia University, New York
Telephone-Based Support Programs for People With Epilepsy
Recruiting
- NYU Langone Health, New York
A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
RecruitingPhase 4
- Clinical Research Site, New York
Brief Interventions for Coping with Distress
Recruiting
- Teachers College, Columbia University, New York
Lay-Delivered Behavioral Activation in Senior Centers
Recruiting
- Hudson Guild Senior Center, New York
- Lincoln Square Senior Center, New York
- Goddard Riverside Community Center and NORC, New York
- and 3 more
An Exploratory Study Examining Biopsychosocial Markers of Anxiety and Depression
RecruitingObservational study
- Singula Institute, 353 Lexington Avenue (Room 600), New York
About Depression
Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.
More about Depression on MedlinePlus
Depression trials in other cities
- Boston, MA52 studies
- Philadelphia, PA26 studies
- Chicago, IL24 studies
- Atlanta, GA24 studies
- Pittsburgh, PA22 studies
- San Diego, CA21 studies
- Charleston, SC19 studies
- Los Angeles, CA17 studies
- Houston, TX17 studies
- Orlando, FL17 studies
- Miami, FL16 studies
- San Francisco, CA15 studies
Other studies in New York City
- Breast Cancer136 studies
- Non-Small Cell Lung Cancer121 studies
- Cancer (all types)109 studies
- Prostate Cancer103 studies
- Metastatic Cancer93 studies
- Colorectal Cancer78 studies
- Ovarian Cancer69 studies
- Lung Cancer60 studies
- Multiple Myeloma60 studies
- Pancreatic Cancer60 studies
- Endometrial Cancer52 studies
- Acute Myeloid Leukemia51 studies
From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.