Home › Depression › Missouri › St. Louis
Depression clinical trials in St. Louis, MO
11 studies for Depression are looking for participants at sites in and around St. Louis (within about 30 miles). Open a study to see who can join and how to contact the study team.
Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →
A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
RecruitingPhase 2
- Seaport Investigator Site, St Louis
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Recruiting
- Washington University School of Medicine, St Louis
E-Mindfulness Approaches for Living After Breast Cancer
RecruitingPhase 3
- Mercy Hospital South, St Louis
- Missouri Baptist Medical Center, St Louis
- Mercy Hospital Saint Louis, St Louis
- and 1 more
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
RecruitingPhase 3
- Arch Clinical Trials, St Louis
Lumateperone for Late-Life Depression
RecruitingPhase 3
- Washington University School of Medicine, St Louis
Efficacy of a Multi-level School Intervention for LGBTQ Youth
RecruitingHealthy volunteers welcome
- Washington University in St. Louis, St Louis
Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) Stage II
RecruitingPhase 2
- Washington University School of Medicine/Barnes-Jewish Hospital, St Louis
Type I Hybrid Effectiveness-Implementation Trial of Primary Care Brief Mindfulness Training for Veterans
Recruiting
- St. Louis VA Medical Center John Cochran Division, St. Louis, MO, St Louis
Digital InteGrated Behavioral treatmeNt for Comorbid obesITy and deprEssion Among Racial and Ethnic Adults Age 50 and Older
Recruiting
- Washington University School of Medicine in St Louis, St Louis
Leveraging mHealth to Promote Opioid Use Recovery and Mental Health Among Residents of a Medium-Sized Midwestern City
RecruitingPhase 2
- Washington University School of Medicine, St Louis
Depression and Driving
RecruitingObservational study
- Washington University School of Medicine, St Louis
About Depression
Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.
More about Depression on MedlinePlus
Depression trials in other cities
- Boston, MA50 studies
- New York City, NY44 studies
- Chicago, IL26 studies
- Atlanta, GA22 studies
- Pittsburgh, PA22 studies
- Philadelphia, PA21 studies
- Charleston, SC18 studies
- San Diego, CA18 studies
- Houston, TX18 studies
- Los Angeles, CA17 studies
- Washington, DC16 studies
- San Francisco, CA15 studies
Other studies in St. Louis
- Non-Small Cell Lung Cancer68 studies
- Breast Cancer63 studies
- Metastatic Cancer52 studies
- Cancer (all types)51 studies
- Colorectal Cancer51 studies
- Prostate Cancer45 studies
- Ovarian Cancer37 studies
- Lung Cancer37 studies
- Pancreatic Cancer33 studies
- Head and Neck Squamous Cell Carcinoma32 studies
- Endometrial Cancer29 studies
- Multiple Myeloma26 studies
From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.