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Depression clinical trials in St. Louis, MO
15 studies for Depression are looking for participants at sites in and around St. Louis (within about 30 miles). Open a study to see who can join and how to contact the study team.
Lumateperone for Late-Life Depression
RecruitingPhase 3
- Washington University School of Medicine, St Louis
A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
RecruitingPhase 2
- Seaport Investigator Site, St Louis
Efficacy of a Multi-level School Intervention for LGBTQ Youth
RecruitingHealthy volunteers welcome
- Washington University in St. Louis, St Louis
Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) Stage II
RecruitingPhase 2
- Washington University School of Medicine/Barnes-Jewish Hospital, St Louis
Type I Hybrid Effectiveness-Implementation Trial of Primary Care Brief Mindfulness Training for Veterans
Recruiting
- St. Louis VA Medical Center John Cochran Division, St. Louis, MO, St Louis
Digital InteGrated Behavioral treatmeNt for Comorbid obesITy and deprEssion Among Racial and Ethnic Adults Age 50 and Older
Recruiting
- Washington University School of Medicine in St Louis, St Louis
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
RecruitingPhase 3
- Arch Clinical Trials, St Louis
E-Mindfulness Approaches for Living After Breast Cancer
RecruitingPhase 3
- Mercy Hospital South, St Louis
- Missouri Baptist Medical Center, St Louis
- Cancer Care Center of O'Fallon, O'Fallon · 16 mi away
A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder
RecruitingPhase 3
- Tekton Research, St Louis
Leveraging mHealth to Promote Opioid Use Recovery and Mental Health Among Residents of a Medium-Sized Midwestern City
RecruitingPhase 2
- Washington University School of Medicine, St Louis
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Recruiting
- Washington University School of Medicine, St Louis
Depression and Driving
RecruitingObservational study
- Washington University School of Medicine, St Louis
Clinical Trial on Agitation in Alzheimer's Dementia
RecruitingPhase 2
- Tekton Research LLC, St Louis
Just-In-Time Adaptive Interventions (JITAIs) in a Digital Mental Health Intervention for Middle-Aged and Older Adults With Chronic Pain
Recruiting
- Washington University in St. Louis School of Medicine, St Louis
INCLUDE Program: A Perioperative Wellness Program Tailored for Black Surgical Patients
Recruiting
- Washington University School of Medicine, St Louis
About Depression
Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.
More about Depression on MedlinePlus
Depression trials in other cities
- Boston, MA51 studies
- New York City, NY46 studies
- Philadelphia, PA25 studies
- Chicago, IL23 studies
- Atlanta, GA23 studies
- Pittsburgh, PA22 studies
- San Diego, CA21 studies
- Charleston, SC19 studies
- Houston, TX18 studies
- Orlando, FL17 studies
- Los Angeles, CA17 studies
- Miami, FL16 studies
Other studies in St. Louis
- Non-Small Cell Lung Cancer71 studies
- Breast Cancer64 studies
- Metastatic Cancer53 studies
- Colorectal Cancer49 studies
- Prostate Cancer47 studies
- Cancer (all types)46 studies
- Lung Cancer39 studies
- Ovarian Cancer37 studies
- Pancreatic Cancer33 studies
- Endometrial Cancer29 studies
- Head and Neck Squamous Cell Carcinoma28 studies
- Heart Failure26 studies
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.