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Depression clinical trials in Seattle, WA

10 studies for Depression are looking for participants at sites in and around Seattle (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

RecruitingPhase 3
  • Seattle Neuropsychiatric Treatment Center, Seattle
Ages 18 to 85 · All sexes · Updated Sep 25, 2026 · NCT06793397

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

RecruitingPhase 2
  • Seattle Neuropsychiatric Treatment Center, Seattle
Ages 18 to 80 · All sexes · Updated Sep 15, 2026 · NCT07002034

PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study

RecruitingPhase 3
  • Seattle NTC, Seattle
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06713616

A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

RecruitingPhase 2
  • Draig Clinical Site, Seattle
Ages 18 to 75 · All sexes · Updated Sep 2, 2026 · NCT07610473

Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression

RecruitingPhase 3
  • VA Puget Sound Health Care System Seattle Division, Seattle, WA, Seattle
Ages 18 to 75 · All sexes · Updated Aug 14, 2026 · NCT07226232

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • Saint Joseph Medical Center Hematology and Oncology - Silverdale, Silverdale · 17 mi away
Ages 18 to 50 · All sexes · Updated Aug 4, 2026 · NCT06748222

TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age

RecruitingObservational study
  • Seattle Children's Hospital, Seattle
18 Months – 11 Years · All sexes · Updated Jul 6, 2026 · NCT07048574

Transforming Care for Individuals With Childhood-onset Systemic Lupus Erythematosus

Recruiting
  • Seattle Children's Hospital, Seattle
Ages 12 to 22 · All sexes · Updated Oct 30, 2025 · NCT06232304

Lay-Delivered Behavioral Activation in Senior Centers

Recruiting
  • Casa Latina, Seattle
  • Centro de la Raza, Seattle
Ages 60 and older · All sexes · Updated Oct 15, 2024 · NCT04621877

About Depression

Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.

More about Depression on MedlinePlus

Depression trials in other cities

Other studies in Seattle

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.