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Depression clinical trials in Knoxville, TN

4 studies for Depression are looking for participants at sites in and around Knoxville (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

RecruitingPhase 2
  • Alliance for Multispecialty Research Clinical, Knoxville
Ages 18 to 80 · All sexes · Updated Sep 15, 2026 · NCT07002034

AI-Based Personalized Exercise Prescription Through Mobile Health on Physical Activity and Health Outcomes in Older Adults: A Feasibility Study

RecruitingHealthy volunteers welcome
Ages 65 and older · All sexes · Updated Aug 20, 2026 · NCT07768670

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • University of Tennessee - Knoxville, Knoxville
Ages 18 to 50 · All sexes · Updated Aug 4, 2026 · NCT06748222

Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence

Recruiting
  • University of Tennessee Medical Center, Knoxville
Ages 18 and older · All sexes · Updated Jan 29, 2026 · NCT06374277

About Depression

Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.

More about Depression on MedlinePlus

Depression trials in other cities

Other studies in Knoxville

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.