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Sickle Cell Disease clinical trials recruiting in the U.S.
107 studies for Sickle Cell Disease are recruiting participants at sites across the United States.
Sickle cell disease is a group of inherited disorders that affect your red blood cells. It can cause pain, anemia, and other problems. Learn about treatments.
Cities with the most studies
- Atlanta, GA22 studies
- Washington, DC20 studies
- Memphis, TN18 studies
- Chicago, IL18 studies
- Philadelphia, PA15 studies
- Birmingham, AL14 studies
- New York City, NY13 studies
- St. Louis, MO12 studies
- Durham, NC10 studies
- Cincinnati, OH10 studies
- Houston, TX10 studies
- Boston, MA10 studies
- Pittsburgh, PA9 studies
- Greenville, NC9 studies
- Columbus, OH9 studies
- The Bronx, NY8 studies
- Cleveland, OH7 studies
- Baltimore, MD7 studies
- Los Angeles, CA7 studies
- Charlotte, NC7 studies
- Oakland, CA7 studies
- Nashville, TN6 studies
- Richmond, VA6 studies
- Augusta, GA5 studies
- Hartford, CT5 studies
- Detroit, MI5 studies
- Phoenix, AZ5 studies
- Indianapolis, IN5 studies
- Jackson, MS5 studies
- New Orleans, LA4 studies
- Arlington, VA4 studies
- Greenville, SC4 studies
- Milwaukee, WI4 studies
- New Haven, CT4 studies
- Greenburgh, NY3 studies
- Newark, NJ3 studies
- Rochester, NY3 studies
- Mobile, AL3 studies
- Little Rock, AR3 studies
- Minneapolis, MN3 studies
By state
- Alabama16 studies
- Arizona5 studies
- Arkansas3 studies
- California18 studies
- Connecticut7 studies
- Delaware6 studies
- District of Columbia10 studies
- Florida9 studies
- Georgia25 studies
- Illinois19 studies
- Indiana5 studies
- Louisiana5 studies
- Maryland17 studies
- Massachusetts10 studies
- Michigan9 studies
- Minnesota5 studies
- Mississippi5 studies
- Missouri13 studies
- New Jersey8 studies
- New York21 studies
- North Carolina18 studies
- Ohio22 studies
- Pennsylvania20 studies
- South Carolina6 studies
- Tennessee22 studies
- Texas11 studies
- Virginia9 studies
- Wisconsin4 studies
Recently updated studies
Exercise in Child Health
RecruitingHealthy volunteers welcome
Ages 10 to 17 · All sexes · Updated Oct 2, 2026 · NCT05359991Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 70 · All sexes · Updated Oct 2, 2026 · NCT03937817A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT04055818Blood Sampling for Research Related to Sickle Cell Disease
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Sep 29, 2026 · NCT00542230A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease (SCD)
RecruitingPhase 3
Ages 12 and older · All sexes · Updated Sep 28, 2026 · NCT07656415Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling
RecruitingEarly phase 1
Ages 18 to 100 · All sexes · Updated Sep 28, 2026 · NCT06313398A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)
RecruitingPhase 3
Ages 12 to 100 · All sexes · Updated Sep 28, 2026 · NCT06439082A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07187973A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
RecruitingPhase 3
Ages 2 and older · All sexes · Updated Sep 18, 2026 · NCT06609226Dietary Intake and Dietary Behaviors in Adults With Sickle Cell Disease
RecruitingObservational study
Ages 18 to 120 · All sexes · Updated Sep 18, 2026 · NCT05170412A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
RecruitingPhase 3
Ages 12 and older · All sexes · Updated Sep 17, 2026 · NCT06612268Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease
RecruitingPhase 1
Ages 18 to 65 · All sexes · Updated Sep 17, 2026 · NCT05904093Tocilizumab for Acute Chest Syndrome
RecruitingPhase 2
Ages 12 and older · All sexes · Updated Sep 15, 2026 · NCT05640271Sickle Cell Disease Biofluid Chip Technology (SCD BioChip)
RecruitingObservational studyHealthy volunteers welcome
Ages 12 and older · All sexes · Updated Sep 11, 2026 · NCT02824471Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell Disease
RecruitingObservational study
Ages 2 to 99 · All sexes · Updated Sep 11, 2026 · NCT06944067Assessing Molecular Mechanisms and Effects of Music Therapy in Youth With Sickle Cell Disease Using Single-cell RNA-sequencing
Recruiting
Ages 8 to 18 · All sexes · Updated Sep 10, 2026 · NCT07562451Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease
RecruitingPhase 1
Ages 8 to 17 · All sexes · Updated Sep 9, 2026 · NCT07226219Early Screening and Treatment of Heart Complication in Sickle Cell Disease
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07023666A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease
RecruitingPhase 1/2Healthy volunteers welcome
Ages 12 to 55 · All sexes · Updated Sep 9, 2026 · NCT06546670SCD Stem Cell Mobilization and Apheresis Using Motixafortide
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06442761Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors
RecruitingPhase 1/2
Ages 4 to 65 · All sexes · Updated Sep 4, 2026 · NCT07599176Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults
RecruitingPhase 2
Ages 5 to 20 · All sexes · Updated Sep 2, 2026 · NCT07369024Escalating Doses of VAS-101 in Subjects With Stable Sickle Cell Disease
RecruitingPhase 1
Ages 18 to 90 · All sexes · Updated Aug 24, 2026 · NCT07566494Cerebrovascular Reactivity Measurements With High-Density Diffuse Optical Tomography
RecruitingHealthy volunteers welcome
Ages 6 to 70 · All sexes · Updated Aug 20, 2026 · NCT07776444A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
RecruitingPhase 1/2Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT06481306From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.