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Colorectal Cancer clinical trials recruiting in the U.S.

336 studies for Colorectal Cancer are recruiting participants at sites across the United States.

Colorectal cancer starts in the colon or rectum. It may not cause symptoms at first. Screening tests can help find it early, when treatment is most effective.

Cities with the most studies

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Recently updated studies

Evaluation for NCI Surgery Branch Clinical Research Protocols

RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT00001823

Colonoscopy vs Stool Testing for Older Adults With Colon Polyps

Recruiting
Ages 65 to 82 · All sexes · Updated Oct 2, 2026 · NCT05612347

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06270706

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer

RecruitingPhase 2
Ages 18 to 72 · All sexes · Updated Oct 2, 2026 · NCT01174121

Family Communications After Genetic Testing

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07143487

Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05176483

Obtaining Solid Tumor Tissue From People Having Biopsy or Surgery for Certain Types of Cancer

RecruitingObservational study
Ages 2 and older · All sexes · Updated Oct 1, 2026 · NCT01915225

177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07189871

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06625775

Developing New Educational Materials About Genetic Testing for a Diverse Group of Cancer Patients

Recruiting
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT04751435

PRE-ISPY Phase I/II Oncology Platform Program

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT05868226

A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07085091

A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT05877599

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.