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Colorectal Cancer clinical trials recruiting in the U.S.
336 studies for Colorectal Cancer are recruiting participants at sites across the United States.
Colorectal cancer starts in the colon or rectum. It may not cause symptoms at first. Screening tests can help find it early, when treatment is most effective.
Cities with the most studies
- Houston, TX102 studies
- New York City, NY77 studies
- Nashville, TN69 studies
- Boston, MA63 studies
- Los Angeles, CA59 studies
- Arlington, VA52 studies
- St. Louis, MO50 studies
- San Antonio, TX46 studies
- Philadelphia, PA44 studies
- Grand Rapids, MI40 studies
- Baldwin Park, CA38 studies
- Seattle, WA34 studies
- Tampa, FL33 studies
- Chicago, IL33 studies
- Dallas, TX33 studies
- Aurora, CO32 studies
- Pittsburgh, PA32 studies
- Queens, NY31 studies
- Baltimore, MD31 studies
- Washington, DC29 studies
- Atlanta, GA29 studies
- Rochester, MN29 studies
- Durham, NC28 studies
- Portland, OR28 studies
- Jacksonville, FL27 studies
- Detroit, MI26 studies
- Phoenix, AZ25 studies
- San Diego, CA25 studies
- Cleveland, OH24 studies
- Columbus, OH24 studies
- Ann Arbor, MI23 studies
- Edison, NJ23 studies
- Santa Monica, CA23 studies
- Denver, CO23 studies
- Madison, WI22 studies
- Oklahoma City, OK22 studies
- Salt Lake City, UT21 studies
- Cincinnati, OH21 studies
- New Haven, CT20 studies
- Minneapolis, MN19 studies
By state
- Alabama12 studies
- Alaska4 studies
- Arizona54 studies
- Arkansas14 studies
- California137 studies
- Colorado56 studies
- Connecticut23 studies
- Delaware9 studies
- District of Columbia17 studies
- Florida99 studies
- Georgia38 studies
- Hawaii5 studies
- Idaho6 studies
- Illinois51 studies
- Indiana27 studies
- Iowa15 studies
- Kansas19 studies
- Kentucky19 studies
- Louisiana18 studies
- Maine4 studies
- Maryland47 studies
- Massachusetts63 studies
- Michigan72 studies
- Minnesota45 studies
- Mississippi6 studies
- Missouri58 studies
- Montana6 studies
- Nebraska22 studies
- Nevada9 studies
- New Hampshire6 studies
- New Jersey36 studies
- New Mexico8 studies
- New York99 studies
- North Carolina44 studies
- North Dakota7 studies
- Ohio63 studies
- Oklahoma22 studies
- Oregon29 studies
- Pennsylvania69 studies
- Rhode Island5 studies
- South Carolina13 studies
- South Dakota11 studies
- Tennessee76 studies
- Texas145 studies
- Utah36 studies
- Vermont4 studies
- Virginia76 studies
- Washington46 studies
- West Virginia5 studies
- Wisconsin36 studies
- Wyoming3 studies
Recently updated studies
Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05673148Evaluation for NCI Surgery Branch Clinical Research Protocols
RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT00001823Colonoscopy vs Stool Testing for Older Adults With Colon Polyps
Recruiting
Ages 65 to 82 · All sexes · Updated Oct 2, 2026 · NCT05612347A Study to Access Intravenous (IV) Telisotuzumab Adizutecan in Combination With IV Bevacizumab Compared to Standard of Care IV Bevacizumabin Combination With Oral Trifluridine and Tipiracil in Adult Participants With Refractory Metastatic Colorectal Cancer
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07525206The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
RecruitingPhase 1/2
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies
RecruitingPhase 1
Ages 18 to 120 · All sexes · Updated Oct 2, 2026 · NCT04847063A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06270706Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06265285Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
RecruitingObservational studyHealthy volunteers welcome
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer
RecruitingPhase 2
Ages 18 to 72 · All sexes · Updated Oct 2, 2026 · NCT01174121Family Communications After Genetic Testing
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07143487A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06760819Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05176483Obtaining Solid Tumor Tissue From People Having Biopsy or Surgery for Certain Types of Cancer
RecruitingObservational study
Ages 2 and older · All sexes · Updated Oct 1, 2026 · NCT01915225PDS01ADC in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer, Intrahepatic Cholangiocarcinoma, or Metastatic Adrenocortical Carcinoma
RecruitingPhase 2
Ages 18 to 120 · All sexes · Updated Oct 1, 2026 · NCT05286814177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07189871Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06625775Developing New Educational Materials About Genetic Testing for a Diverse Group of Cancer Patients
Recruiting
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT04751435Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06324357PRE-ISPY Phase I/II Oncology Platform Program
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT05868226A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07085091The Impact of PReOPerative Exercise and NutritionaL Optimization on Perioperative Outcomes for Patients Undergoing Treatment for Rectal Cancer: The PROPEL Trial
Recruiting
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06565052The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07285044Testing the Combination of Anti-Cancer Drugs, Botensilimab (AGEN1181) and Balstilimab (AGEN2034), After Standard Treatment for Colorectal Cancer, Combat Trial
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07551596A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT05877599From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.