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Depression clinical trials in Jacksonville, FL

10 studies for Depression are looking for participants at sites in and around Jacksonville (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

RecruitingPhase 2
  • Clinical Neuroscience Solutions Inc. - Jacksonville, Jacksonville
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07621237

A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

RecruitingPhase 3
  • CNS Healthcare, Jacksonville
Ages 18 to 85 · All sexes · Updated Sep 25, 2026 · NCT06793397

A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

RecruitingPhase 2
  • Seaport Investigator Site, Jacksonville
Ages 18 to 65 · All sexes · Updated Sep 14, 2026 · NCT07065240

Subanesthetic Ketamine Infusions for Depressive Symptoms in Intensive Care Unit Patients

RecruitingPhase 2
  • Mayo Clinic, Jacksonville
Ages 18 to 99 · All sexes · Updated Sep 2, 2026 · NCT07639359

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • Mayo Clinic in Florida, Jacksonville
Ages 18 to 50 · All sexes · Updated Aug 4, 2026 · NCT06748222

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

RecruitingPhase 3
  • Clinical Neuroscience Solutions, Inc., Jacksonville
Ages 18 to 74 · All sexes · Updated Aug 3, 2026 · NCT06775379

Virtual Reality Intervention to Improve Psychological Symptom Burden for Cancer Patients Undergoing Treatment

Recruiting
  • Mayo Clinic in Florida, Jacksonville
Ages 18 to 90 · All sexes · Updated Apr 2, 2026 · NCT07221409

Potential Benefits of Parent Child Interaction Therapy (PCIT)

RecruitingObservational studyHealthy volunteers welcome
  • UF Health Psychiatry San Jose, Jacksonville
Ages 18 to 89 · All sexes · Updated Feb 12, 2026 · NCT06827951

A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

RecruitingPhase 4
  • Clinical Research Site, Jacksonville
Ages 18 to 65 · All sexes · Updated Jan 23, 2025 · NCT06223880

About Depression

Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.

More about Depression on MedlinePlus

Depression trials in other cities

Other studies in Jacksonville

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.