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Depression clinical trials in Durham, NC

15 studies for Depression are looking for participants at sites in and around Durham (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Brexanolone Lifting Outcomes Of Moms

RecruitingPhase 3
  • Lipocine Investigational Site, Chapel Hill · 10 mi away
Ages 15 to 45 · Women · Updated Sep 16, 2026 · NCT07822321

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

RecruitingPhase 2
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 to 80 · All sexes · Updated Sep 15, 2026 · NCT07002034

Teachers Leading the Front Lines - North Carolina (Tealeaf-NC)

Recruiting
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 5 to 99 · All sexes · Updated Sep 3, 2026 · NCT06587230

Neuroscience of Psychotherapy for Depression

Recruiting
  • Carolina Center for Neurostimulation, Chapel Hill · 10 mi away
Ages 18 to 30 · All sexes · Updated Aug 27, 2026 · NCT06696001

Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors

Recruiting
  • Duke University Medical Center, Durham
Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT06538246

A New Intervention to Improve Function in Veterans With Anxiety and Depression

RecruitingPhase 2
  • Durham VA Medical Center, Durham, NC, Durham
Ages 18 to 65 · All sexes · Updated Jul 7, 2026 · NCT06188923

TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age

RecruitingObservational study
  • University of North Carolina School of Medicine, Chapel Hill · 10 mi away
18 Months – 11 Years · All sexes · Updated Jul 6, 2026 · NCT07048574

CARED : A Novel Rapid Treatment Paradigm for Depression

Recruiting
  • Carolina Center for Neurostimulation, Chapel Hill · 10 mi away
Ages 18 to 70 · All sexes · Updated Jun 25, 2026 · NCT07507370

Examining the Effects of Estradiol on Neural and Molecular Response to Reward

RecruitingPhase 4
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 45 to 55 · Women · Updated Apr 29, 2026 · NCT05282277

SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Immigrant Families

RecruitingHealthy volunteers welcome
  • Duke School of Nursing, Durham
Ages 12 to 100 · All sexes · Updated Apr 9, 2026 · NCT06627764

Adolescent Mood During Puberty and Testosterone

RecruitingHealthy volunteers welcome
  • Carolina Crossing B, Suite 1, Chapel Hill · 10 mi away
Ages 11 to 14 · All sexes · Updated Jan 14, 2026 · NCT06072677

Depression, Aging, Stress and Heart Health Study

RecruitingHealthy volunteers welcome
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 44 to 55 · Women · Updated Dec 22, 2025 · NCT05570721

Supporting Health in Veterans With Heart Failure

RecruitingHealthy volunteers welcome
  • VA Clinic - Durham, Durham
Ages 18 and older · All sexes · Updated Nov 13, 2025 · NCT05839067

Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depression

RecruitingPhase 4
  • University of North Carolina, Chapel Hill, Chapel Hill · 10 mi away
Ages 18 to 45 · Women · Updated Oct 29, 2025 · NCT06610305

Comparing Cognitive-Behavioral Therapy Versus Mindfulness-Based Therapy for Autistic Adults

Recruiting
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 18, 2025 · NCT06060860

About Depression

Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.

More about Depression on MedlinePlus

Depression trials in other cities

Other studies in Durham

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.