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Depression clinical trials in Columbus, OH

11 studies for Depression are looking for participants at sites in and around Columbus (within about 30 miles). Open a study to see who can join and how to contact the study team.

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

RecruitingPhase 2
  • The Ohio State University, Department of Psychiatry, Columbus
Ages 18 to 80 · All sexes · Updated Sep 15, 2026 · NCT07002034

A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

RecruitingPhase 2
  • Draig Clinical Site, Columbus
Ages 18 to 75 · All sexes · Updated Sep 2, 2026 · NCT07610473

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • Ohio State University Comprehensive Cancer Center, Columbus
  • Mount Carmel East Hospital, Columbus
  • Mount Carmel Grove City Hospital, Grove City · 7 mi away
  • and 2 more
Ages 18 to 50 · All sexes · Updated Aug 4, 2026 · NCT06748222

A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety

RecruitingPhase 2
  • The Ohio State University Department of Psychiatry, Columbus
Ages 21 to 65 · All sexes · Updated Jul 23, 2026 · NCT06820723

Virtual Poetry Workshops to Enhance Patient Well Being and Reduce Anxiety

Recruiting
  • Ohio State University Wexner Medical Center, Columbus
Ages 18 and older · All sexes · Updated Jul 21, 2026 · NCT07717541

Teenthrive 2: Treatments for Improving Mood in Teens

Recruiting
  • Nationwide Children's Hospital, Columbus
Ages 12 to 18 · All sexes · Updated Jun 10, 2026 · NCT07475845

Psilocybin-Assisted Therapy for the Treatment of Major Depressive Disorder in Patients With Non-Small Cell Lung Cancer

RecruitingPhase 2
  • Ohio State University Comprehensive Cancer Center, Columbus
Ages 18 and older · All sexes · Updated May 14, 2026 · NCT07216404

A Precision Medicine Approach to Target Engagement for Emotion Regulation

Recruiting
  • Ohio State University, Columbus
Ages 18 and older · All sexes · Updated May 11, 2026 · NCT05651295

A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

RecruitingPhase 2
  • The Ohio State University, Columbus
Ages 18 to 65 · All sexes · Updated May 11, 2026 · NCT06524830

Mechanisms of Rumination Change in Adolescent Depression

Recruiting
  • Nationwide Children's Hospital, Columbus
  • The Ohio State University, Columbus
Ages 14 to 17 · All sexes · Updated Aug 11, 2025 · NCT03859297

About Depression

Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.

More about Depression on MedlinePlus

Depression trials in other cities

Other studies in Columbus

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.