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Heart Failure clinical trials in Orlando, FL

16 studies for Heart Failure are looking for participants at sites in and around Orlando (within about 30 miles). Open a study to see who can join and how to contact the study team.

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

RecruitingPhase 3
  • AdventHealth, Orlando
Ages 18 to 85 · All sexes · Updated Sep 24, 2026 · NCT06736574

A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

RecruitingPhase 3
  • Clinical Site Partners, LLC, Winter Park · 5 mi away
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06424288

A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

RecruitingPhase 3
  • Clinical Site Partners, LLC, Winter Park · 5 mi away
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06935370

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

RecruitingPhase 3
  • AdventHealth Orlando, Orlando
  • Orlando Health Heart Institute, Orlando
  • Guardian Research Organization LLC, Winter Park · 5 mi away
  • and 1 more
Ages 18 to 99 · All sexes · Updated Sep 16, 2026 · NCT07037459

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

RecruitingPhase 3
  • Research Site, Orlando
Ages 40 and older · All sexes · Updated Sep 15, 2026 · NCT06677060

A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction

RecruitingPhase 1
  • Flourish Research, Winter Park · 5 mi away
Ages 18 to 100 · All sexes · Updated Sep 10, 2026 · NCT07465653

Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

Recruiting
  • Advent Health, Orlando
Ages 18 to 100 · All sexes · Updated Sep 9, 2026 · NCT06310031

Feasibility and Efficacy Study of the CardioPulmonary Management (CPM) System in Patients With Chronic Heart Failure

Recruiting
  • Orlando Health, Orlando
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT05650541

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

RecruitingPhase 3
  • Cardiovascular Institute of Orlando, Orlando
  • Guardian Research Org LLC, Winter Park · 5 mi away
  • K2 Medical Research, Maitland · 6 mi away
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07567001

Alleviant ALLAY-HF Study

Recruiting
  • Advent Health Orlando, Orlando
Ages 40 and older · All sexes · Updated Aug 14, 2026 · NCT05685303

Assessment of CCM in HF With Higher Ejection Fraction

Recruiting
  • AdventHealth Orlando, Orlando
  • Revival Clinical Research, Orlando
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT05064709

A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy

RecruitingPhase 2
  • AdventHealth Orlando, Orlando
  • Guardian Research Org LLC, Winter Park · 5 mi away
Ages 40 to 84 · All sexes · Updated Aug 5, 2026 · NCT06979362

A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

RecruitingPhase 2
  • Clinical Site Partners, LLC dba Flourish Research, Winter Park · 5 mi away
Ages 18 to 79 · All sexes · Updated May 27, 2026 · NCT06991257

CCM OPEN HF Registry

RecruitingObservational study
  • AdventHealth Orlando, Orlando
Ages 18 and older · All sexes · Updated Apr 23, 2026 · NCT07112924

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

Recruiting
  • Advent Health Hospital, Orlando
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT03142152

Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

RecruitingPhase 3
  • AdventHealth, Orlando
Ages 18 to 75 · All sexes · Updated Mar 24, 2026 · NCT06217302

About Heart Failure

Heart failure, or congestive heart failure (CHF), means the heart can't pump enough blood. Learn about the signs, symptoms, and causes.

More about Heart Failure on MedlinePlus

Heart Failure trials in other cities

Other studies in Orlando

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.