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Heart Failure clinical trials in Orlando, FL

16 studies for Heart Failure are looking for participants at sites in and around Orlando (within about 30 miles). Open a study to see who can join and how to contact the study team.

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A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction

RecruitingPhase 1
  • Flourish Research, Winter Park · 5 mi away
Ages 18 to 100 · All sexes · Updated Nov 12, 2026 · NCT07465653

A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

RecruitingPhase 3
  • Flourish Research, Winter Park · 5 mi away
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06424288

A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

RecruitingPhase 3
  • Flourish Research, Winter Park · 5 mi away
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06935370

Barostim-Enabled NEurohormonal Intervention For Improving Treatment of Heart Failure

Recruiting
  • AdventHealth Orlando, Orlando
Ages 18 and older · All sexes · Updated Nov 9, 2026 · NCT07232030

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

RecruitingPhase 3
  • AdventHealth, Orlando
Ages 18 to 85 · All sexes · Updated Nov 4, 2026 · NCT06736574

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

RecruitingPhase 3
  • AdventHealth Orlando, Orlando
  • Orlando Health Heart Institute, Orlando
  • Guardian Research Organization LLC, Winter Park · 5 mi away
  • and 1 more
Ages 18 to 99 · All sexes · Updated Oct 29, 2026 · NCT07037459

CCM OPEN HF Registry

RecruitingObservational study
  • AdventHealth Orlando, Orlando
Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT07112924

A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

RecruitingPhase 2
  • Clinical Site Partners, LLC dba Flourish Research, Winter Park · 5 mi away
Ages 18 to 79 · All sexes · Updated Oct 23, 2026 · NCT06991257

Assessment of CCM in HF With Higher Ejection Fraction

Recruiting
  • AdventHealth Orlando, Orlando
  • Clinical One Research, Orlando
Ages 18 and older · All sexes · Updated Oct 23, 2026 · NCT05064709

Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

RecruitingPhase 3
  • Research Site, Orlando
Ages 40 and older · All sexes · Updated Oct 21, 2026 · NCT06677060

A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy

RecruitingPhase 2
  • AdventHealth Orlando, Orlando
  • Guardian Research Org LLC, Winter Park · 5 mi away
Ages 40 to 84 · All sexes · Updated Oct 5, 2026 · NCT06979362

Feasibility and Efficacy Study of the CardioPulmonary Management (CPM) System in Patients With Chronic Heart Failure

Recruiting
  • Orlando Health, Orlando
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT05650541

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

RecruitingPhase 3
  • Cardiovascular Institute of Orlando, Orlando
  • Guardian Research Org LLC, Winter Park · 5 mi away
  • K2 Medical Research, Maitland · 6 mi away
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07567001

Alleviant ALLAY-HF Study

Recruiting
  • Advent Health Orlando, Orlando
Ages 40 and older · All sexes · Updated Aug 14, 2026 · NCT05685303

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

Recruiting
  • Advent Health Hospital, Orlando
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT03142152

Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

RecruitingPhase 3
  • AdventHealth, Orlando
Ages 18 to 75 · All sexes · Updated Mar 24, 2026 · NCT06217302

About Heart Failure

Heart failure, or congestive heart failure (CHF), means the heart can't pump enough blood. Learn about the signs, symptoms, and causes.

More about Heart Failure on MedlinePlus

Heart Failure trials in other cities

Other studies in Orlando

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.