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Depression clinical trials in Irvine, CA

4 studies for Depression are looking for participants at sites in and around Irvine (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder

RecruitingPhase 3
  • Irvine Clinical Research, Irvine
Ages 18 to 75 · All sexes · Updated Oct 1, 2026 · NCT07775300

E-Mindfulness Approaches for Living After Breast Cancer

RecruitingPhase 3
  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
  • Kaiser Permanente-Irvine, Irvine
Ages 18 to 50 · All sexes · Updated Aug 4, 2026 · NCT06748222

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

RecruitingPhase 3
  • Irvine Clinical Research, Irvine
Ages 18 to 74 · All sexes · Updated Aug 3, 2026 · NCT06775379

Positive Affect Treatment for Adolescents With Early Life Adversity

RecruitingHealthy volunteers welcome
  • University of California Irvine, Irvine
Ages 12 to 16 · All sexes · Updated May 6, 2026 · NCT06273137

About Depression

Depression is a serious medical illness. It affects almost 7 percent of U.S. adults. It causes feelings of sadness, hopelessness, and frustration that do not go away. Learn about treatments.

More about Depression on MedlinePlus

Depression trials in other cities

Other studies in Irvine

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.