🔎 Trials Near Me

Home › Durham, NC

Healthy volunteer studies in Durham, NC

162 studies at sites in and around Durham accept healthy volunteers — people without the condition being studied. Many studies pay participants for their time and travel; the amount is set by each study, so ask the study team.

Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network

RecruitingObservational studyHealthy volunteers welcome
  • Duke University Health System, Durham
1 Month – 100 Years · All sexes · Updated Oct 2, 2026 · NCT02450851

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Durham VA Medical Center, Durham
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

Neoadjuvant Durvalumab and Tremelimumab With and Without Chemotherapy for Mesothelioma

RecruitingPhase 1/2Healthy volunteers welcome
  • Duke Cancer Institute, Durham
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05932199

pH1N1 Blinded Challenge Study

RecruitingPhase 1Healthy volunteers welcome
  • Duke Vaccine and Trials Unit, Durham
Ages 18 to 55 · All sexes · Updated Oct 2, 2026 · NCT07110532

Low Dose Aspirin for the Prevention of Postpartum Related Breast Cancer

RecruitingPhase 2Healthy volunteers welcome
  • University of North Carolina, Chapel Hill · 10 mi away
Ages 18 to 45 · Women · Updated Oct 1, 2026 · NCT05557877

Role of Alpha-to-beta Cell Communication to Adapt Insulin Secretion to Insulin Resistance.

RecruitingPhase 1Healthy volunteers welcome
  • Duke Center for Living, Durham
Ages 18 to 60 · All sexes · Updated Oct 1, 2026 · NCT07224334

A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

RecruitingHealthy volunteers welcome
  • Duke University Hospital, Durham
  • Durham Veterans Affairs Medical Center (Durham VAMC), Durham
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 55 and older · All sexes · Updated Sep 28, 2026 · NCT06112418

Environmental Risk Factors for the Anti-synthetase Syndrome

RecruitingObservational studyHealthy volunteers welcome
  • NIEHS Clinical Research Unit (CRU), Research Triangle Park · 7 mi away
Ages 2 to 100 · All sexes · Updated Sep 28, 2026 · NCT01276470

Natural History of the Human Biological Response to Environmental Exposure and Injury

RecruitingObservational studyHealthy volunteers welcome
  • NIEHS Clinical Research Unit (CRU), Research Triangle Park · 7 mi away
Ages 18 to 90 · All sexes · Updated Sep 28, 2026 · NCT04888923

Evaluation of the Acceptability, Appropriateness, and Feasibility/Usability of a Metastatic Breast-cancer Specific Prognostic Calculator Among Clinicians

RecruitingObservational studyHealthy volunteers welcome
  • University of North Carolina, Chapel Hill · 10 mi away
All ages · All sexes · Updated Sep 28, 2026 · NCT05440929

Neural Correlates of Real World Spatial Navigation in Humans

RecruitingHealthy volunteers welcome
  • Duke University, Durham
Ages 18 to 90 · All sexes · Updated Sep 28, 2026 · NCT04874220

Immune Cell Response to Stimuli

RecruitingObservational studyHealthy volunteers welcome
  • NIEHS Clinical Research Unit (CRU), Research Triangle Park · 7 mi away
Ages 18 to 65 · All sexes · Updated Sep 28, 2026 · NCT00397280

BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies

RecruitingPhase 3Healthy volunteers welcome
  • Duke Vaccine and Trials Unit, Durham
  • Duke University - Main Hospital and Clinics, Durham
  • Duke University - Main Hospital and Clinics, Durham
1 Day – 49 Years · All sexes · Updated Sep 25, 2026 · NCT07160244

A Phase 3 Study of Revaccination in Subsequent Pregnancies With Bivalent RSV Vaccine and Duration of Protection of a Single Dose

RecruitingPhase 3Healthy volunteers welcome
  • Duke University - Main Hospital and Clinics, Durham
  • Duke University - Main Hospital and Clinics, Durham
Ages 0 and older · All sexes · Updated Sep 24, 2026 · NCT06866405

Adult and Juvenile Myositis

RecruitingObservational studyHealthy volunteers welcome
  • NIEHS Clinical Research Unit (CRU), Research Triangle Park · 7 mi away
Ages 2 to 100 · All sexes · Updated Sep 24, 2026 · NCT00017914

Early Dental Risk Screening for Pediatric Sleep-Disordered Breathing

RecruitingObservational studyHealthy volunteers welcome
  • UNC Adams School of Dentistry, Chapel Hill · 10 mi away
Ages 8 to 13 · All sexes · Updated Sep 23, 2026 · NCT07581938

American Lung Association (ALA) Lung Health Cohort

RecruitingObservational studyHealthy volunteers welcome
  • Duke University, Durham
Ages 25 to 35 · All sexes · Updated Sep 23, 2026 · NCT04543461

Nutrition for Precision Health, Powered by the All of Us

RecruitingHealthy volunteers welcome
  • University of North Carolina at Chapel Hill - Chapel Hill Clinic, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT05701657

Study of the Effect of Innate on the Inflammatory Response to Endotoxin

RecruitingObservational studyHealthy volunteers welcome
  • NIEHS Clinical Research Unit (CRU), Research Triangle Park · 7 mi away
Ages 18 to 100 · All sexes · Updated Sep 22, 2026 · NCT01143480

NASA Exercise Prebreathe Study

RecruitingHealthy volunteers welcome
  • Duke University Medical Center, Durham
Ages 30 to 60 · All sexes · Updated Sep 22, 2026 · NCT07702539

Supporting Just-In-Time Consent for Prenatal Screening: The INFORM Study

RecruitingHealthy volunteers welcome
  • University of North Carolina, Chapel Hill · 10 mi away
Ages 18 and older · Women · Updated Sep 22, 2026 · NCT07557303

Cessation or Reduction of Alcohol Consumption in Veterans: A Randomized Controlled Trial for Alcohol Use Disorder (CRAVE)

RecruitingPhase 3Healthy volunteers welcome
  • Durham VA Medical Center, Durham, NC, Durham
Ages 18 to 80 · All sexes · Updated Sep 21, 2026 · NCT07218354

Identifying Patterns in the Breath of Individuals With Breast Cancer

RecruitingObservational studyHealthy volunteers welcome
  • Duke University Medical Cente, Durham
Ages 40 to 74 · Women · Updated Sep 18, 2026 · NCT06512350

A Study on the Efficacy of a Vaccine Against Influenza in Adults ≥65 Years of Age

RecruitingPhase 3Healthy volunteers welcome
  • GSK Investigational Site, Durham
Ages 65 and older · All sexes · Updated Sep 18, 2026 · NCT07805707

Personalized Environment and Genes Study

RecruitingObservational studyHealthy volunteers welcome
  • NIEHS Clinical Research Unit (CRU), Research Triangle Park · 7 mi away
  • University of North Carolina, Chapel Hill · 10 mi away
Ages 18 to 120 · All sexes · Updated Sep 16, 2026 · NCT00341237

Reproductive Axis Maturation in the Early Post-Menarchal Years

RecruitingObservational studyHealthy volunteers welcome
  • NIEHS Clinical Research Unit (CRU), Research Triangle Park · 7 mi away
Ages 8 to 65 · Women · Updated Sep 16, 2026 · NCT03986021

Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

RecruitingHealthy volunteers welcome
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 50 and older · All sexes · Updated Sep 15, 2026 · NCT06687603

Observational Pharmaco-Epidemiology Research & Analysis

RecruitingObservational studyHealthy volunteers welcome
  • Epividian, Durham
Ages 0 and older · All sexes · Updated Sep 11, 2026 · NCT03813862

A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)

RecruitingPhase 3Healthy volunteers welcome
  • ACCOMPLISH-2 Research Site, Durham
Ages 18 to 79 · All sexes · Updated Sep 11, 2026 · NCT07654374

Stress and Menstrual Health

RecruitingHealthy volunteers welcome
  • Duke University, Durham
Ages 22 to 38 · Women · Updated Sep 9, 2026 · NCT07566260

A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and Older

RecruitingPhase 3Healthy volunteers welcome
  • Duke Vaccine and Trials Unit, Durham
Ages 65 and older · All sexes · Updated Sep 9, 2026 · NCT07282665

A Study to Learn About How a New Pneumococcal Vaccine Works in Infants.

RecruitingPhase 3Healthy volunteers welcome
  • Duke Vaccine and Trials Unit, Durham
  • Durham Pediatrics at North Duke Street, Durham
42 Days – 211 Days · All sexes · Updated Sep 8, 2026 · NCT07629440

Comparing a Workplace Resilience and a Physical Activity Intervention on Early Childhood Educators Well-being

RecruitingHealthy volunteers welcome
  • UNC Center for Health Promotion and Disease Prevention, Chapel Hill · 10 mi away
Ages 18 to 99 · All sexes · Updated Sep 8, 2026 · NCT06919952

Daily Upgrade Trial

RecruitingHealthy volunteers welcome
  • Applied Physiology Laboratory, Chapel Hill · 10 mi away
Ages 25 to 45 · Women · Updated Sep 3, 2026 · NCT07792603

ADRC Clinical Cohort (Alzheimer's Disease)

RecruitingObservational studyHealthy volunteers welcome
  • Duke University, Durham
Ages 25 to 80 · All sexes · Updated Sep 3, 2026 · NCT06703541

Molecular Residual Disease Assessment in a Representative Diverse Population of Patients With Early-stage Breast Cancer

RecruitingHealthy volunteers welcome
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT07025785

The Vanguard Study: Testing a New Way to Screen for Cancer

RecruitingHealthy volunteers welcome
  • Durham VA Medical Center, Durham
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 45 to 75 · All sexes · Updated Sep 2, 2026 · NCT06995898

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

RecruitingPhase 4Healthy volunteers welcome
  • PREVENTABLE Tele-Site, Durham
  • Duke University, Durham
  • University of North Carolina, Chapel Hill · 10 mi away
Ages 75 and older · All sexes · Updated Sep 1, 2026 · NCT04262206

Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans

RecruitingHealthy volunteers welcome
  • Duke University Health System, Durham
Ages 18 to 70 · All sexes · Updated Aug 31, 2026 · NCT05120635

Using PrEP, Doing It for Ourselves

RecruitingHealthy volunteers welcome
  • Duke University School of Nursing, Durham
Ages 18 and older · Women · Updated Aug 28, 2026 · NCT06638892

The HOPE Biobank Resource (BMT CTN 2402 HOPE)

RecruitingObservational studyHealthy volunteers welcome
  • Duke University Medical Center, Durham
All ages · All sexes · Updated Aug 27, 2026 · NCT07227155

Duke APOL1 Research Biorepository

RecruitingObservational studyHealthy volunteers welcome
  • Duke University Medical Center, Durham
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT04160507

Enhancing PrEP Uptake and Retention Among Latine TGW and GBM in the South Using Long-Acting Injectable PrEP

RecruitingPhase 4Healthy volunteers welcome
  • El Centro Hispano, Durham
Ages 18 and older · Men · Updated Aug 26, 2026 · NCT07218211

The Impact of Music Intervention on Sleep

RecruitingHealthy volunteers welcome
  • Duke University School of Nursing, Durham
Ages 18 to 100 · All sexes · Updated Aug 25, 2026 · NCT06088810

Health Education Approach to Lung Screening

RecruitingHealthy volunteers welcome
  • University of North Carolina-Chapel Hill, Carrboro · 11 mi away
Ages 50 to 80 · All sexes · Updated Aug 25, 2026 · NCT06070870

The SEQUENCE Trial

RecruitingHealthy volunteers welcome
  • University of North Carolina, Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Aug 25, 2026 · NCT06676956

ASSESS ALL ALS Study

RecruitingObservational studyHealthy volunteers welcome
  • Duke University, Durham
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06578195

Safer Drinking Spaces Study

RecruitingHealthy volunteers welcome
  • RTI International, Durham
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT07527988

PREVENT ALL ALS Study

RecruitingObservational studyHealthy volunteers welcome
  • Duke University, Durham
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06581861

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

RecruitingObservational studyHealthy volunteers welcome
  • Duke University Health System, Durham
Ages 0 to 20 · All sexes · Updated Aug 21, 2026 · NCT04278404

Trial of Ovarian Vein and Pelvic Vein Embolization in Women With Chronic Pelvic Pain and Pelvic Varices

RecruitingHealthy volunteers welcome
  • UNC School of Medicine, Chapel Hill · 10 mi away
Ages 18 to 75 · Women · Updated Aug 20, 2026 · NCT06168058

Stress Trajectories and Anhedonia in Adolescence Research Study

RecruitingHealthy volunteers welcome
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 13 to 15 · All sexes · Updated Aug 17, 2026 · NCT07040449

IAP-086-1: A Phase 1 Single Ascending Dose First-Time in Human Study

RecruitingPhase 1Healthy volunteers welcome
  • Duke Early Phase Clinical Research Unit, Durham
  • University of North Carolina, Chapel Hill · 10 mi away
Ages 18 to 70 · All sexes · Updated Aug 17, 2026 · NCT07596888

Prototyping a Device for Automating Stool and Urine Output Tracking

RecruitingHealthy volunteers welcome
  • Duke University, Durham
Ages 18 and older · All sexes · Updated Aug 12, 2026 · NCT05438199

Neuromodulation of Memory in Aging

RecruitingHealthy volunteers welcome
  • Duke University Hospital, Durham
Ages 18 to 75 · All sexes · Updated Aug 11, 2026 · NCT05460468

AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance

RecruitingHealthy volunteers welcome
  • Duke Eye Center, Durham
Ages 50 to 89 · All sexes · Updated Aug 10, 2026 · NCT06619405

Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma

RecruitingObservational studyHealthy volunteers welcome
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT00288119

Expanding the Support of Family Caregivers of Diverse Patients With Cancer and Diabetes

RecruitingHealthy volunteers welcome
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 18 to 99 · All sexes · Updated Aug 10, 2026 · NCT07061652

A Study to Learn About a COVID-19 Vaccine in Healthy Adults 18 Through 64 Years of Age

RecruitingPhase 4Healthy volunteers welcome
  • Duke Vaccine and Trials Unit, Durham
Ages 18 to 64 · All sexes · Updated Aug 7, 2026 · NCT07730450

Shield Post-Approval Study Protocol

RecruitingObservational studyHealthy volunteers welcome
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
  • University of North Carolina at Chapel Hill, Hillsborough · 13 mi away
Ages 45 to 81 · All sexes · Updated Aug 7, 2026 · NCT06880055

Robotic OCT for ER Anterior Eye Exams

RecruitingHealthy volunteers welcome
  • Duke Eye Center, Durham
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT06566339

Pain With Dementia

RecruitingHealthy volunteers welcome
  • Duke University Medical Center, Durham
Ages 50 and older · All sexes · Updated Aug 5, 2026 · NCT06854718

Optimize Pediatric OCT Imaging

RecruitingObservational studyHealthy volunteers welcome
  • Duke University Eye Center, Durham
All ages · All sexes · Updated Aug 5, 2026 · NCT06139523

Strength Training Exercise in Pediatric Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma (STEP-ALL)

RecruitingHealthy volunteers welcome
  • University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 6 and older · All sexes · Updated Aug 3, 2026 · NCT07634653

Self-collection for HPV Testing to Improve Cervical Cancer Prevention (SHIP) Trial (LMI-001-A-S04)

RecruitingHealthy volunteers welcome
  • UNC Lineberger Comprehensive Cancer Center, Chapel Hill · 10 mi away
Ages 25 and older · Women · Updated Jul 31, 2026 · NCT07281430

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

RecruitingObservational studyHealthy volunteers welcome
  • University of North Carolina, Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT04363684

APOL1 Genotyping CTA Clinical Performance Study

RecruitingHealthy volunteers welcome
  • Almac Diagnostic Services LLC, Durham
Ages 18 to 70 · All sexes · Updated Jul 27, 2026 · NCT06839833

Prescription of Letrozole for Uterine Myoma

RecruitingPhase 4Healthy volunteers welcome
  • Duke University, Durham
Ages 21 to 53 · Women · Updated Jul 22, 2026 · NCT06143631

Focusing on the Menopausal Transition to Improve Mid-Life Women's Health

RecruitingPhase 2/3Healthy volunteers welcome
  • University of North Carolina, School of Medicine, Chapel Hill · 10 mi away
Ages 45 to 55 · Women · Updated Jul 21, 2026 · NCT06975111

Comprehensive HHT Outcomes Registry of the United States (CHORUS)

RecruitingObservational studyHealthy volunteers welcome
  • University of North Carolina, Chapel Hill, Chapel Hill · 10 mi away
All ages · All sexes · Updated Jul 17, 2026 · NCT06259292

Deep Functional Phenotyping of the ALA Lung Health Cohort

RecruitingObservational studyHealthy volunteers welcome
  • Duke University, Durham
Ages 25 to 35 · All sexes · Updated Jul 17, 2026 · NCT06177717

Transcranial Magnetic Brain Stimulation to Reduce Cannabis Use in Heavy Cannabis Users

RecruitingHealthy volunteers welcome
  • Duke University Medical Center, Durham
Ages 18 to 65 · All sexes · Updated Jul 13, 2026 · NCT05401929

MRI Neurofeedback and Brain Circuits Related to Motivation in Healthy Participants

RecruitingHealthy volunteers welcome
  • Center for Cognitive Neuroscience, Durham
Ages 18 to 45 · All sexes · Updated Jul 10, 2026 · NCT05929898

Eating Disorders Genetics Initiative 2

RecruitingObservational studyHealthy volunteers welcome
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 12 to 99 · All sexes · Updated Jul 8, 2026 · NCT06594913

Genetic and Environmental Risk Factors for Hemorrhagic Stroke

RecruitingObservational studyHealthy volunteers welcome
  • Duke University, Durham
Ages 18 and older · All sexes · Updated Jul 2, 2026 · NCT00682695

19F MRI in Healthy Children and Children With Mild Cystic Fibrosis Lung Disease

RecruitingObservational studyHealthy volunteers welcome
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 6 to 17 · All sexes · Updated Jul 2, 2026 · NCT06066723

Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease

RecruitingObservational studyHealthy volunteers welcome
  • The University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
All ages · All sexes · Updated Jun 29, 2026 · NCT00807482

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

RecruitingEarly phase 1Healthy volunteers welcome
  • Duke University Health System, Durham
Ages 1 to 21 · All sexes · Updated Jun 29, 2026 · NCT06333899

Cochlear Implants in Young Children With SSD

RecruitingHealthy volunteers welcome
  • The Children's Cochlear Implant Center at UNC, Durham
7 Months – 71 Months · All sexes · Updated Jun 26, 2026 · NCT05775367

Practice Facilitation as a Strategy to Improve Alcohol Treatment Adoption and Implementation in HIV Care

RecruitingHealthy volunteers welcome
  • University of North Carolina, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Jun 26, 2026 · NCT05241990

Consumer Perceptions of Alcoholic Beverages

RecruitingHealthy volunteers welcome
  • University of North Carolina at Chapel Hill, Department of Radiation Oncology, Chapel Hill · 10 mi away
Ages 21 to 99 · All sexes · Updated Jun 25, 2026 · NCT07226271

Artificial Intelligence (AI)-Enhanced Pretreatment Peer-review Process to Improve Patient Safety in Radiation Oncology

RecruitingHealthy volunteers welcome
  • University of North Carolina at Chapel Hill, Department of Radiation Oncology, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT07463833

Animal Assisted Therapy in Pediatric Dentistry

RecruitingHealthy volunteers welcome
  • General & Oral Health Center, Chapel Hill · 10 mi away
Ages 4 to 8 · All sexes · Updated Jun 12, 2026 · NCT05464888

NIEHS Repository of Stored Biological Samples for Future Use

RecruitingObservational studyHealthy volunteers welcome
  • NIEHS Clinical Research Unit (CRU), Research Triangle Park · 7 mi away
Ages 18 to 100 · All sexes · Updated Jun 11, 2026 · NCT05666739

Increasing Germline Genetic Testing for Patients With Cancer

RecruitingHealthy volunteers welcome
  • Durham VA Medical Center, Durham
All ages · All sexes · Updated Jun 9, 2026 · NCT07307664

Translation of Acoustic Angiography: Contrast Enhanced Super Resolution (CESR) Imaging

RecruitingPhase 2Healthy volunteers welcome
  • The University of North Carolina, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT07225114

A Study of LY4006895 in Healthy Participants With Early Symptomatic Alzheimer's Disease (AD)

RecruitingPhase 1Healthy volunteers welcome
  • Duke Early Phase Research Unit, Durham
Ages 45 to 85 · All sexes · Updated Jun 4, 2026 · NCT06657768

The Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry

RecruitingObservational studyHealthy volunteers welcome
  • Duke University Medical Center, Durham
Ages 15 to 55 · Women · Updated Jun 4, 2026 · NCT06030063

Neuroimaging of Opioid Phase (OPAL)

RecruitingHealthy volunteers welcome
  • Duke University Medical Center, Durham
Ages 18 and older · Women · Updated Jun 3, 2026 · NCT05905419

Ultrasound Simulation Case-based Workshop Implementation and Impact Assessment

RecruitingHealthy volunteers welcome
  • Duke University Health System, Durham
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT06960837

Cardiac point-of Care Ultrasound Training Pathway for Emergency Department Advanced Practice Providers

RecruitingHealthy volunteers welcome
  • Duke University Health System, Durham
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT07159269

Caring for the Carer

RecruitingHealthy volunteers welcome
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 to 99 · All sexes · Updated May 27, 2026 · NCT07167641

Virtual Reality Visual Field Testing as an Alternative in Childhood Eye Disease

RecruitingHealthy volunteers welcome
  • Duke University Medical Center, Durham
Ages 4 to 21 · All sexes · Updated May 26, 2026 · NCT05150197

RaDIANT Health Systems Intervention

RecruitingHealthy volunteers welcome
  • Duke Transplant Center, Durham
Ages 18 to 80 · All sexes · Updated May 26, 2026 · NCT07033117

Retinal Microanatomy in Retinopathy of Prematurity (BabySTEPS2)

RecruitingHealthy volunteers welcome
  • Duke University Eye Center, Durham
All ages · All sexes · Updated May 22, 2026 · NCT04995341

Gathering Online for Dialogue and Discussion to Enhance Social Support

RecruitingHealthy volunteers welcome
  • RTI International, Durham
Ages 18 to 30 · All sexes · Updated May 19, 2026 · NCT05753683

Study to Evaluate the REMEDY SPECTRUM GV IM Spacer Nail in the Treatment of Ankle-Related Infections

RecruitingPhase 2Healthy volunteers welcome
  • Duke University Medical Center, Durham
Ages 21 and older · All sexes · Updated May 19, 2026 · NCT06428448

Macrophage Regulation of Ozone-Induced Lung Inflammation

RecruitingPhase 1Healthy volunteers welcome
  • Duke University Medical Center, Durham
Ages 18 to 55 · All sexes · Updated May 15, 2026 · NCT05773001

Neural Mechanisms of Light Driven Analgesia

RecruitingHealthy volunteers welcome
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated May 13, 2026 · NCT07245303

Pilot Study of Mindset Moments Among Adolescent and Young Adult Cancer Survivors

RecruitingHealthy volunteers welcome
  • Duke Cancer Institute, Durham
Ages 19 to 25 · All sexes · Updated May 6, 2026 · NCT06732375

Child-Adult Relationship Enhancement in Primary Care (PriCARE) / Criando Niños Con CARIÑO (CARIÑO)

RecruitingHealthy volunteers welcome
  • University of North Carolina Chapel Hill, Chapel Hill · 10 mi away
18 Months – 99 Years · All sexes · Updated May 1, 2026 · NCT05233150

Woodsmoke Exposure, Influenza Infection, and Nasal Immunity

RecruitingPhase 4Healthy volunteers welcome
  • Mary Ellen Jones, Chapel Hill · 10 mi away
Ages 18 to 49 · All sexes · Updated Apr 30, 2026 · NCT06841913

Women s Health Awareness Community Resiliency, Environmental Action and Collaborations for Health (REACH) Equity

RecruitingObservational studyHealthy volunteers welcome
  • NIEHS Clinical Research Unit (CRU), Research Triangle Park · 7 mi away
Ages 18 to 100 · Women · Updated Apr 28, 2026 · NCT04983251

Accountability for Care Through Undoing Racism & Equity for Moms

RecruitingHealthy volunteers welcome
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 12 to 99 · Women · Updated Apr 17, 2026 · NCT05484804

The Validation Study of Bioelectronics

RecruitingHealthy volunteers welcome
  • Kenan Laboratories at the University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 to 99 · All sexes · Updated Apr 17, 2026 · NCT05397951

Impacts of Sugar Warnings on Weight Bias

RecruitingHealthy volunteers welcome
  • UNC MiniMart Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Apr 16, 2026 · NCT07346001

Evaluating a National Person-Centered Training Program to Strengthen the Dementia Care Workforce

RecruitingHealthy volunteers welcome
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT06239688

SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Immigrant Families

RecruitingHealthy volunteers welcome
  • Duke School of Nursing, Durham
Ages 12 to 100 · All sexes · Updated Apr 9, 2026 · NCT06627764

Azithromycin Prophylaxis for PRElabor CEsarean DElivery Trial

RecruitingPhase 3Healthy volunteers welcome
  • Duke University, Durham
  • University of North Carolina - Chapel Hill, Chapel Hill · 10 mi away
All ages · Women · Updated Apr 9, 2026 · NCT06605118

Aspirin Dose Escalation for the Prevention of Recurrent Preterm Delivery Trial

RecruitingPhase 3Healthy volunteers welcome
  • Duke University, Durham
  • University of North Carolina - Chapel Hill, Chapel Hill · 10 mi away
Ages 14 and older · Women · Updated Apr 9, 2026 · NCT06980025

The WISER Study: Web Based Methods for Enhancing Resilience

RecruitingHealthy volunteers welcome
  • Duke University Health System, Durham
Ages 18 and older · All sexes · Updated Apr 8, 2026 · NCT05636072

DILIN - Prospective Study

RecruitingObservational studyHealthy volunteers welcome
  • Univeristy of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 2 and older · All sexes · Updated Apr 8, 2026 · NCT00345930

AI-CARE: Artificial Intelligence for Cardiovascular Analysis and Risk Evaluation

RecruitingObservational studyHealthy volunteers welcome
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 22 and older · All sexes · Updated Apr 6, 2026 · NCT07438327

Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking

RecruitingEarly phase 1Healthy volunteers welcome
  • Duke University Medical Center, Durham
Ages 18 to 21 · All sexes · Updated Apr 2, 2026 · NCT05665465

Neonatal Platelet Transfusion Threshold Trial

RecruitingHealthy volunteers welcome
  • Duke University, Durham
1 Hour – 48 Hours · All sexes · Updated Mar 25, 2026 · NCT06676904

Advancing Pediatric Retinal Imaging With Auto-aligned OCT

RecruitingHealthy volunteers welcome
  • Duke University Eye Center, Durham
1 Month · All sexes · Updated Mar 25, 2026 · NCT06841575

Femoral Peri-arterial Local Anesthetic Injection Via Peri-arterial Perineural Catheter Reverses Tourniquet Associated Ischemic Hypertension

RecruitingPhase 4Healthy volunteers welcome
  • Duke University Hospital, Durham
Ages 18 to 75 · All sexes · Updated Mar 23, 2026 · NCT04454203

Kaempferol Absorption and Pharmacokinetics Evaluation

RecruitingHealthy volunteers welcome
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 to 70 · All sexes · Updated Mar 23, 2026 · NCT07322406

Dissolved Phase HXe-129 MRI: A Novel Biomarker to Quantify Pulmonary Pathology

RecruitingPhase 2/3Healthy volunteers welcome
  • Duke University, Durham
Ages 18 to 35 · All sexes · Updated Mar 17, 2026 · NCT06856525

Safety of RSV Preventive Monoclonal Antibody

RecruitingPhase 4Healthy volunteers welcome
  • Duke University, Durham
6 Weeks – 30 Weeks · All sexes · Updated Mar 16, 2026 · NCT07158814

SenseToKnow Autism Screening Device Validation Study

RecruitingObservational studyHealthy volunteers welcome
  • Duke University, Durham
16 Months – 36 Months · All sexes · Updated Mar 6, 2026 · NCT05874466

Pilot Study for Speculum Free Cervical Cancer Screening

RecruitingHealthy volunteers welcome
  • Duke University, Durham
Ages 21 to 65 · Women · Updated Mar 6, 2026 · NCT04107181

Cervical Cancer Detection Using Optical Spectroscopy

RecruitingHealthy volunteers welcome
  • Duke University Medical Center, Durham
Ages 18 and older · Women · Updated Mar 6, 2026 · NCT00900575

Telephone-based Physical Activity Coaching or Self Monitored Physical Activity to Improve Physical Function in Older Adults Who Are Undergoing Surgery for Lung Cancer and Their Caregivers

RecruitingHealthy volunteers welcome
  • Duke University, Durham
Ages 18 and older · All sexes · Updated Mar 5, 2026 · NCT06196008

Physical Activity and Community EmPOWERment Project

RecruitingHealthy volunteers welcome
  • University of North Carolina, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Feb 23, 2026 · NCT06740162

Sugary Drink Labeling Study

RecruitingHealthy volunteers welcome
  • The University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Feb 17, 2026 · NCT07294053

129Xe MRI Cardiopulmonary

RecruitingPhase 2Healthy volunteers welcome
  • Duke University Medical Center, Durham
Ages 18 and older · All sexes · Updated Feb 4, 2026 · NCT06038630

Retinal Imaging in Neurodegenerative Disease

RecruitingObservational studyHealthy volunteers welcome
  • Duke University Medical Center, Durham
Ages 18 and older · All sexes · Updated Feb 4, 2026 · NCT03233646

Project humAn dieTary daTa rEtuRN

RecruitingHealthy volunteers welcome
  • Duke University, Durham
12 Months · All sexes · Updated Jan 29, 2026 · NCT06266689

Maternal Newborn Health Registry

RecruitingObservational studyHealthy volunteers welcome
  • University of North Carolina, Chapel Hill · 10 mi away
All ages · All sexes · Updated Jan 21, 2026 · NCT01073475

Nutrition and Obesity in Under-Represented Populations: Food Insecurity Research to Advance Science and Improve Health

RecruitingHealthy volunteers welcome
  • North Duke Street Pediatrics, Durham
12 Months – 24 Months · All sexes · Updated Jan 16, 2026 · NCT06116422

Hyperpolarized 129Xe MRI for Imaging Pulmonary Function

RecruitingPhase 2Healthy volunteers welcome
  • Duke University Medical Center, Durham
Ages 18 and older · All sexes · Updated Jan 16, 2026 · NCT01280994

Adolescent Mood During Puberty and Testosterone

RecruitingHealthy volunteers welcome
  • Carolina Crossing B, Suite 1, Chapel Hill · 10 mi away
Ages 11 to 14 · All sexes · Updated Jan 14, 2026 · NCT06072677

Maternal Autoimmune Disease Research Alliance (MADRA) Registry

RecruitingObservational studyHealthy volunteers welcome
  • Duke University, Durham
All ages · Women · Updated Jan 8, 2026 · NCT03276923

Depression, Aging, Stress and Heart Health Study

RecruitingHealthy volunteers welcome
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 44 to 55 · Women · Updated Dec 22, 2025 · NCT05570721

Mobile Neurofeedback for Low Back Pain

RecruitingHealthy volunteers welcome
  • Duke University Medical Center, Department of Psychiatry, Durham
Ages 18 to 90 · All sexes · Updated Dec 17, 2025 · NCT05669027

Virtual Village for Young Parents

RecruitingHealthy volunteers welcome
  • RTI International, Durham
Ages 16 to 21 · All sexes · Updated Dec 15, 2025 · NCT07226401

Assessment of AI Program 'DRISTi' as a Screening Tool

RecruitingObservational studyHealthy volunteers welcome
  • New Century Ophthalmology - Oxford, Oxford · 28 mi away
Ages 21 and older · All sexes · Updated Dec 9, 2025 · NCT07222293

Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia

RecruitingPhase 4Healthy volunteers welcome
  • Duke University Medical Center, Durham
Ages 3 to 17 · All sexes · Updated Dec 5, 2025 · NCT06576830

BREAST Choice Decision Tool R21 - AIM2

RecruitingHealthy volunteers welcome
  • The University of North Carolina, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Nov 25, 2025 · NCT06817226

Supporting Health in Veterans With Heart Failure

RecruitingHealthy volunteers welcome
  • VA Clinic - Durham, Durham
Ages 18 and older · All sexes · Updated Nov 13, 2025 · NCT05839067

Achieving Understanding of the Natural History of Sickle Cell Trait (AUNT)

RecruitingObservational studyHealthy volunteers welcome
  • Duke University, Durham
  • University of North Carolina, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Nov 6, 2025 · NCT06071377

Aimovig Pregnancy Exposure Registry

RecruitingObservational studyHealthy volunteers welcome
  • IQVIA Virtual Site, Durham
Ages 18 to 99 · Women · Updated Nov 4, 2025 · NCT06150781

Beta-Blocker Influences on Inflammatory and Neural Responses to Stress

RecruitingPhase 4Healthy volunteers welcome
  • Social Neuroscience and Health Laboratory, Chapel Hill · 10 mi away
Ages 18 to 30 · All sexes · Updated Oct 29, 2025 · NCT06263452

Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal Bupivacaine for Orthopedic Wrist Surgery

RecruitingPhase 3Healthy volunteers welcome
  • UNC Chapel Hill, Chapel Hill · 10 mi away
Ages 18 and older · All sexes · Updated Oct 24, 2025 · NCT06179004

Oxygen Toxicity: Mechanisms in Humans

RecruitingHealthy volunteers welcome
  • Duke University Health Sustem, Durham
Ages 18 to 45 · All sexes · Updated Oct 23, 2025 · NCT05761756

Comparative Efficacy of Organizational Skills Training (OST) and Mindfulness-Based Intervention (MBI)

RecruitingHealthy volunteers welcome
  • Duke University, Durham
Ages 13 to 17 · All sexes · Updated Oct 20, 2025 · NCT07089745

Genetics of Charcot Marie Tooth (CMT) - Modifiers of CMT1A, New Causes of CMT2

RecruitingObservational studyHealthy volunteers welcome
  • University of North Carolina, Chapel Hill · 10 mi away
All ages · All sexes · Updated Oct 7, 2025 · NCT01193088

Intraoperative OCT Guidance of Intraocular Surgery II

RecruitingObservational studyHealthy volunteers welcome
  • Duke University Eye Center, Durham
4 Weeks · All sexes · Updated Oct 6, 2025 · NCT03713268

COA-APTIC Cognitive Interview Study of Caregiver and Clinician Assessment of Acute Pain in Infants and Young Children

RecruitingObservational studyHealthy volunteers welcome
  • Duke Clinical Research Institute, Durham
Ages 18 and older · All sexes · Updated Sep 9, 2025 · NCT06164028

SC2i Tissue and Data Repository Protocol

RecruitingObservational studyHealthy volunteers welcome
  • Duke University Health Systems, Durham
Ages 18 and older · All sexes · Updated Sep 4, 2025 · NCT02182180

A Novel Surgical Irrigation Solution in Post-Mastectomy Reconstruction: Evaluating Xperience™

RecruitingHealthy volunteers welcome
  • University of North Carolina at Chapel Hill Hospital, Chapel Hill · 10 mi away
Ages 18 and older · Women · Updated Aug 7, 2025 · NCT06649890

Specialty Compared to Oncology Delivered Palliative Care for Patients With Acute Myeloid Leukemia

RecruitingHealthy volunteers welcome
  • Duke University, Durham
  • University of North Carolina at Chapel Hill, Chapel Hill · 10 mi away
Ages 18 to 120 · All sexes · Updated Jul 25, 2025 · NCT05237258

Addressing Barriers to Achieving Cardiometabolic Disorders Prevention and Treatment Goals for PLWH in the SE US

RecruitingObservational studyHealthy volunteers welcome
  • Duke University - Duke Study Site, Durham
Ages 18 and older · All sexes · Updated Jul 24, 2025 · NCT05129345

Registry of Arthrex Hand and Wrist Products

RecruitingObservational studyHealthy volunteers welcome
  • Duke University, Durham
Ages 18 and older · All sexes · Updated Jun 26, 2025 · NCT05046600

Supplementing L-citrulline to Overweight Late Asthma oNset Phenotypes

RecruitingPhase 2Healthy volunteers welcome
  • Duke University (Asthma, Allergy and Airway Center), Durham
Ages 18 to 65 · All sexes · Updated Jun 10, 2025 · NCT03885245

Adverse Adolescent Pathways to Substance Use

RecruitingHealthy volunteers welcome
  • The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill · 10 mi away
Ages 12 to 14 · All sexes · Updated May 18, 2025 · NCT06977178

Treatment to Lift Facial Lax Skin and Improve Facial Wrinkles Using Precise and Lift Applicators

RecruitingHealthy volunteers welcome
  • Skin Wellness Dermatology Associates, Durham
Ages 35 to 80 · All sexes · Updated May 13, 2025 · NCT06333067

The ME&MG Digital Solution for Autonomous Assessment of Myasthenia Gravis

RecruitingHealthy volunteers welcome
  • Duke University, Durham
Ages 18 and older · All sexes · Updated Apr 11, 2025 · NCT05564936

Project Mountain - Comparing SpO2 and SaO2 for Accuracy

RecruitingObservational studyHealthy volunteers welcome
  • Duke University Medical Center, Durham
All ages · All sexes · Updated Apr 2, 2025 · NCT06372106

Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism

RecruitingPhase 1/2Healthy volunteers welcome
  • Biomedical Research Imaging Center Marsico Hall (UNC), Chapel Hill · 10 mi away
  • Clinical and Translational Research Center (CTRC) Burnett-Womack Building (UNC), Chapel Hill · 10 mi away
Ages 18 to 45 · All sexes · Updated Mar 30, 2025 · NCT04328337

Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

RecruitingObservational studyHealthy volunteers welcome
  • Duke University, Durham
Ages 18 and older · All sexes · Updated Feb 28, 2024 · NCT01574053

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.