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Major Depressive Disorder clinical trials recruiting in the U.S.
156 studies for Major Depressive Disorder are recruiting participants at sites across the United States.
Cities with the most studies
- New York City, NY37 studies
- Boston, MA31 studies
- Atlanta, GA25 studies
- Philadelphia, PA23 studies
- Orlando, FL19 studies
- Miami, FL18 studies
- Chicago, IL17 studies
- Tampa, FL17 studies
- Houston, TX16 studies
- San Diego, CA16 studies
- Little Rock, AR14 studies
- Orange, CA13 studies
- Austin, TX13 studies
- Las Vegas, NV13 studies
- Jacksonville, FL12 studies
- Glendale, CA12 studies
- Los Angeles, CA12 studies
- Concord, CA12 studies
- Washington, DC11 studies
- Grand Prairie, TX11 studies
- Cincinnati, OH11 studies
- Bellevue, WA10 studies
- Newton, MA10 studies
- Baltimore, MD9 studies
- Birmingham, AL9 studies
- Dallas, TX9 studies
- Brooklyn, NY9 studies
- Hartford, CT9 studies
- Oklahoma City, OK9 studies
- O'Fallon, MO9 studies
- Oceanside, CA9 studies
- Columbus, OH8 studies
- San Bernardino, CA8 studies
- Everett, WA8 studies
- San Francisco, CA8 studies
- Cleveland, OH8 studies
- Phoenix, AZ8 studies
- Hollywood, FL8 studies
- Hialeah, FL8 studies
- St. Louis, MO7 studies
By state
- Alabama15 studies
- Arizona13 studies
- Arkansas15 studies
- California52 studies
- Colorado10 studies
- Connecticut16 studies
- District of Columbia3 studies
- Florida32 studies
- Georgia33 studies
- Idaho3 studies
- Illinois20 studies
- Indiana4 studies
- Iowa5 studies
- Louisiana5 studies
- Maryland21 studies
- Massachusetts45 studies
- Michigan5 studies
- Minnesota7 studies
- Mississippi3 studies
- Missouri16 studies
- Nebraska3 studies
- Nevada13 studies
- New Jersey10 studies
- New Mexico4 studies
- New York48 studies
- North Carolina12 studies
- Ohio29 studies
- Oklahoma12 studies
- Oregon5 studies
- Pennsylvania27 studies
- South Carolina8 studies
- Tennessee6 studies
- Texas38 studies
- Utah14 studies
- Virginia7 studies
- Washington21 studies
- Wisconsin3 studies
Recently updated studies
Acceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Mental Illness
Recruiting
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05491538NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder
RecruitingObservational studyHealthy volunteers welcome
Ages 8 to 70 · All sexes · Updated Oct 2, 2026 · NCT05669703Natural History of Depression, Bipolar Disorder and Suicide Risk
RecruitingObservational study
Ages 18 to 120 · All sexes · Updated Oct 1, 2026 · NCT06462196A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder
RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Oct 1, 2026 · NCT07775300A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Oct 1, 2026 · NCT07573176Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium
Recruiting
Ages 22 to 85 · All sexes · Updated Sep 29, 2026 · NCT07594483Precision Depression Adalimumab Trial
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07845604JAK Signaling in Depression
RecruitingPhase 2
Ages 25 to 55 · All sexes · Updated Sep 28, 2026 · NCT07003997Characterization and Treatment of Adolescent Depression
RecruitingObservational studyHealthy volunteers welcome
Ages 11 to 25 · All sexes · Updated Sep 28, 2026 · NCT03388606Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
RecruitingPhase 3
Ages 18 to 74 · All sexes · Updated Sep 25, 2026 · NCT06559306A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07621237Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 25, 2026 · NCT05850689A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder
RecruitingPhase 3
Ages 12 to 17 · All sexes · Updated Sep 25, 2026 · NCT07227454A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Sep 25, 2026 · NCT06793397Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder
RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 24, 2026 · NCT06830044The Medically Tailored Groceries and Mental Health Study
Recruiting
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07779707Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Sep 22, 2026 · NCT03065335Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders
RecruitingPhase 2Healthy volunteers welcome
Ages 8 to 65 · All sexes · Updated Sep 22, 2026 · NCT00018057DBS for TRD With the Medtronic Percept PC
Recruiting
Ages 25 to 70 · All sexes · Updated Sep 22, 2026 · NCT05773755Accelerated TMS for Perinatal Depression
Recruiting
Ages 18 to 55 · Women · Updated Sep 18, 2026 · NCT06968390A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
RecruitingPhase 4
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07105111Lumateperone for Late-Life Depression
RecruitingPhase 3
Ages 60 and older · All sexes · Updated Sep 16, 2026 · NCT07623135Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
RecruitingPhase 1Healthy volunteers welcome
Ages 21 to 45 · All sexes · Updated Sep 15, 2026 · NCT06480201Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study
Recruiting
Ages 18 to 85 · All sexes · Updated Sep 15, 2026 · NCT07217223Pattern Separation in Major Depressive Disorder
RecruitingPhase 1
Ages 18 to 50 · All sexes · Updated Sep 15, 2026 · NCT07139834From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.