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Melanoma clinical trials recruiting in the U.S.
197 studies for Melanoma are recruiting participants at sites across the United States.
Melanoma is the most serious type of skin cancer. Most have a black or black-blue area. Learn the 'ABCDE' of what to watch for and treatment options.
Cities with the most studies
- Houston, TX59 studies
- New York City, NY38 studies
- Los Angeles, CA34 studies
- Nashville, TN33 studies
- Pittsburgh, PA31 studies
- Boston, MA26 studies
- Philadelphia, PA23 studies
- San Francisco, CA22 studies
- Durham, NC21 studies
- Atlanta, GA21 studies
- St. Louis, MO21 studies
- Salt Lake City, UT21 studies
- Columbus, OH21 studies
- Arlington, VA20 studies
- Dallas, TX20 studies
- Tampa, FL19 studies
- Denver, CO19 studies
- San Diego, CA18 studies
- Aurora, CO18 studies
- Washington, DC17 studies
- Seattle, WA17 studies
- Cincinnati, OH17 studies
- Grand Rapids, MI17 studies
- Rochester, MN16 studies
- Queens, NY16 studies
- Jacksonville, FL16 studies
- San Antonio, TX15 studies
- Madison, WI15 studies
- Edison, NJ15 studies
- Portland, OR15 studies
- Orlando, FL15 studies
- Chicago, IL15 studies
- Orange, CA14 studies
- Cleveland, OH13 studies
- Ann Arbor, MI12 studies
- Minneapolis, MN12 studies
- Omaha, NE12 studies
- Austin, TX11 studies
- Baltimore, MD11 studies
- Richmond, VA11 studies
By state
- Alabama12 studies
- Alaska5 studies
- Arizona26 studies
- Arkansas13 studies
- California70 studies
- Colorado32 studies
- Connecticut13 studies
- Delaware6 studies
- District of Columbia7 studies
- Florida55 studies
- Georgia23 studies
- Hawaii3 studies
- Idaho8 studies
- Illinois22 studies
- Indiana14 studies
- Iowa12 studies
- Kansas15 studies
- Kentucky21 studies
- Louisiana9 studies
- Maine4 studies
- Maryland24 studies
- Massachusetts29 studies
- Michigan31 studies
- Minnesota29 studies
- Mississippi3 studies
- Missouri23 studies
- Montana8 studies
- Nebraska16 studies
- Nevada6 studies
- New Hampshire6 studies
- New Jersey24 studies
- New Mexico11 studies
- New York50 studies
- North Carolina31 studies
- North Dakota9 studies
- Ohio40 studies
- Oklahoma14 studies
- Oregon15 studies
- Pennsylvania47 studies
- Rhode Island5 studies
- South Carolina10 studies
- South Dakota7 studies
- Tennessee40 studies
- Texas77 studies
- Utah26 studies
- Vermont5 studies
- Virginia34 studies
- Washington25 studies
- West Virginia7 studies
- Wisconsin20 studies
- Wyoming3 studies
Recently updated studies
Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Melanoma
RecruitingObservational studyHealthy volunteers welcome
4 Weeks โ 99 Years ยท All sexes ยท Updated Oct 2, 2026 ยท NCT00040352Evaluation for NCI Surgery Branch Clinical Research Protocols
RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Oct 2, 2026 ยท NCT00001823Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma
RecruitingPhase 2
Ages 18 to 120 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT05155033Phase 1/2 Study of Intravenous Injection of STX-003 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab
RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Oct 2, 2026 ยท NCT07751042A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors
RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Oct 2, 2026 ยท NCT06270706Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Oct 2, 2026 ยท NCT06265285Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
RecruitingObservational studyHealthy volunteers welcome
Ages 40 to 75 ยท All sexes ยท Updated Oct 2, 2026 ยท NCT05334069A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Oct 1, 2026 ยท NCT06172478Neoadjuvant Ipilimumab/Nivolumab for Patients With Recurrent, High Risk, Resectable Melanoma
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Oct 1, 2026 ยท NCT06365619NeoAdjuvant, Spare-Adjuvant (NASA) in Stage IIIB-IV (M1a) Melanoma
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 30, 2026 ยท NCT07740941The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 30, 2026 ยท NCT07285044Hepzato Kit and Opdualag for Metastatic Melanoma and Liver Metastasis
RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 29, 2026 ยท NCT07281924A Study of BI 3810944 in Patients With Advanced Cancer
RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Sep 29, 2026 ยท NCT07224425Phase 1 Study of PF-08046033 in Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Sep 28, 2026 ยท NCT07519655A Clinical Study of Intismeran Autogene (V940) and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 28, 2026 ยท NCT06961006DESTINY-PANTUMOUR04
RecruitingObservational study
Ages 18 to 130 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT07124000BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 25, 2026 ยท NCT05136196A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Sep 25, 2026 ยท NCT06246916Neoadjuvant Immune Checkpoint Blockade + a Prebiotic Food-enriched Dietary Intervention to Optimize Immune Response in Melanoma: NEO-PreFED
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 25, 2026 ยท NCT06548789Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.
RecruitingPhase 3
Ages 18 to 70 ยท All sexes ยท Updated Sep 24, 2026 ยท NCT05727904A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children Using Pathology and Genetic Information
RecruitingPhase 2
Up to age 25 ยท All sexes ยท Updated Sep 24, 2026 ยท NCT07621614Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 24, 2026 ยท NCT06047379Pan-tumor MRD Study
RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Sep 24, 2026 ยท NCT06605404Comparing the Effectiveness of Less Invasive Procedures With the Current Standard of Care for the Treatment of Older Adults With Early-Stage Melanoma
RecruitingPhase 3
Ages 75 and older ยท All sexes ยท Updated Sep 24, 2026 ยท NCT07068074Intratumoral N17350 in Advanced Solid Tumors
RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 23, 2026 ยท NCT07339176From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.