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Heart Failure clinical trials recruiting in the U.S.

220 studies for Heart Failure are recruiting participants at sites across the United States.

Heart failure, or congestive heart failure (CHF), means the heart can't pump enough blood. Learn about the signs, symptoms, and causes.

Cities with the most studies

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Recently updated studies

Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging

RecruitingObservational studyHealthy volunteers welcome
Ages 7 to 100 · All sexes · Updated Oct 5, 2026 · NCT03581318

ELEVATE-HFpEF Clinical Study

Recruiting
Ages 40 and older · All sexes · Updated Oct 2, 2026 · NCT06678841

Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function

RecruitingPhase 3
Ages 18 to 130 · All sexes · Updated Oct 2, 2026 · NCT06307652

Early Feasibility Study - Edwards APTURE Transcatheter Shunt System

Recruiting
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT03523416

A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06424288

Infusing Needed Iron to Target Insufficiency in Adults Treated for Evidence of Heart Failure

Recruiting
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07467668

A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction

RecruitingPhase 1
Ages 18 to 100 · All sexes · Updated Oct 1, 2026 · NCT07465653

HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

RecruitingObservational studyHealthy volunteers welcome
Ages 30 and older · All sexes · Updated Sep 29, 2026 · NCT05873634

Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

RecruitingObservational studyHealthy volunteers welcome
Ages 30 and older · All sexes · Updated Sep 29, 2026 · NCT06517186

BiVACOR® Total Artificial Heart Early Feasibility Study

Recruiting
Ages 18 to 70 · All sexes · Updated Sep 28, 2026 · NCT06174103

A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07761117

: Vascular Function in Health and Disease

RecruitingPhase 1Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT02966665

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Sep 24, 2026 · NCT06736574

Evaluation of Liver Stiffness Performance, by FibroScan®, to Detect Elevated Central Venous Pressure (CVP)

Recruiting
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07222813

Barostim-Enabled NEurohormonal Intervention For Improving Treatment of Heart Failure

Recruiting
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07232030

A Study of LY3971297 in Participants With Heart Failure

RecruitingPhase 1
Ages 18 to 65 · All sexes · Updated Sep 22, 2026 · NCT07547540

Tezspire Cardiac Events PASS

RecruitingObservational study
Ages 12 to 130 · All sexes · Updated Sep 18, 2026 · NCT06951867

Cholate Clearance in Fontan and Heart Failure

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07009132

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

RecruitingPhase 3
Ages 18 to 99 · All sexes · Updated Sep 16, 2026 · NCT07037459

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.