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Heart Failure clinical trials recruiting in the U.S.
220 studies for Heart Failure are recruiting participants at sites across the United States.
Heart failure, or congestive heart failure (CHF), means the heart can't pump enough blood. Learn about the signs, symptoms, and causes.
Cities with the most studies
- New York City, NY51 studies
- Boston, MA44 studies
- Dallas, TX42 studies
- Houston, TX36 studies
- Cleveland, OH33 studies
- Chicago, IL31 studies
- Philadelphia, PA31 studies
- San Francisco, CA29 studies
- Durham, NC26 studies
- St. Louis, MO26 studies
- Atlanta, GA25 studies
- Kansas City, MO25 studies
- Cincinnati, OH24 studies
- Baltimore, MD24 studies
- Indianapolis, IN23 studies
- San Diego, CA23 studies
- Rochester, MN22 studies
- Ann Arbor, MI22 studies
- Jacksonville, FL21 studies
- Minneapolis, MN21 studies
- Los Angeles, CA20 studies
- Nashville, TN19 studies
- Washington, DC19 studies
- Pittsburgh, PA19 studies
- Aurora, CO18 studies
- Phoenix, AZ18 studies
- Tampa, FL18 studies
- Austin, TX18 studies
- Charleston, SC18 studies
- Salt Lake City, UT17 studies
- Seattle, WA17 studies
- Portland, OR17 studies
- Columbus, OH16 studies
- Richmond, VA16 studies
- Milwaukee, WI16 studies
- Orlando, FL16 studies
- Mountain View, CA15 studies
- Arlington, VA15 studies
- Harrisburg, PA14 studies
- Miami, FL14 studies
By state
- Alabama23 studies
- Arizona31 studies
- Arkansas11 studies
- California65 studies
- Colorado23 studies
- Connecticut21 studies
- Delaware3 studies
- District of Columbia12 studies
- Florida50 studies
- Georgia28 studies
- Idaho6 studies
- Illinois44 studies
- Indiana29 studies
- Iowa10 studies
- Kansas19 studies
- Kentucky21 studies
- Louisiana18 studies
- Maine6 studies
- Maryland28 studies
- Massachusetts45 studies
- Michigan37 studies
- Minnesota43 studies
- Mississippi7 studies
- Missouri40 studies
- Nebraska21 studies
- Nevada7 studies
- New Jersey27 studies
- New Mexico4 studies
- New York57 studies
- North Carolina42 studies
- Ohio55 studies
- Oklahoma17 studies
- Oregon17 studies
- Pennsylvania45 studies
- Rhode Island4 studies
- South Carolina30 studies
- South Dakota15 studies
- Tennessee33 studies
- Texas67 studies
- Utah22 studies
- Vermont8 studies
- Virginia38 studies
- Washington26 studies
- West Virginia8 studies
- Wisconsin20 studies
Recently updated studies
Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure
Recruiting
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT07069738A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy
RecruitingPhase 2
Ages 40 to 84 · All sexes · Updated Oct 5, 2026 · NCT06979362Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging
RecruitingObservational studyHealthy volunteers welcome
Ages 7 to 100 · All sexes · Updated Oct 5, 2026 · NCT03581318ELEVATE-HFpEF Clinical Study
Recruiting
Ages 40 and older · All sexes · Updated Oct 2, 2026 · NCT06678841Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
RecruitingPhase 3
Ages 18 to 130 · All sexes · Updated Oct 2, 2026 · NCT06307652Early Feasibility Study - Edwards APTURE Transcatheter Shunt System
Recruiting
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT03523416A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06424288A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
Recruiting
Ages 18 to 85 · All sexes · Updated Oct 1, 2026 · NCT07214376Infusing Needed Iron to Target Insufficiency in Adults Treated for Evidence of Heart Failure
Recruiting
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07467668A Phase 1 AAV Gene Therapy Trial Evaluating Safety and Preliminary Efficacy of RP-A701 in Subjects With BAG3 Dilated Cardiomyopathy
RecruitingPhase 1
Ages 18 to 65 · All sexes · Updated Oct 1, 2026 · NCT07137338A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction
RecruitingPhase 1
Ages 18 to 100 · All sexes · Updated Oct 1, 2026 · NCT07465653A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06935370NT-ProBNP-based Heart Failure Screening and Prevention Trial in Patients With Type 2 Diabetes: STRONG-DM Study
Recruiting
All ages · All sexes · Updated Sep 29, 2026 · NCT06593327HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets
RecruitingObservational studyHealthy volunteers welcome
Ages 30 and older · All sexes · Updated Sep 29, 2026 · NCT05873634Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction
RecruitingObservational studyHealthy volunteers welcome
Ages 30 and older · All sexes · Updated Sep 29, 2026 · NCT06517186BiVACOR® Total Artificial Heart Early Feasibility Study
Recruiting
Ages 18 to 70 · All sexes · Updated Sep 28, 2026 · NCT06174103A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07761117: Vascular Function in Health and Disease
RecruitingPhase 1Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT02966665Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Sep 24, 2026 · NCT06736574Evaluation of Liver Stiffness Performance, by FibroScan®, to Detect Elevated Central Venous Pressure (CVP)
Recruiting
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07222813Barostim-Enabled NEurohormonal Intervention For Improving Treatment of Heart Failure
Recruiting
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07232030A Study of LY3971297 in Participants With Heart Failure
RecruitingPhase 1
Ages 18 to 65 · All sexes · Updated Sep 22, 2026 · NCT07547540Tezspire Cardiac Events PASS
RecruitingObservational study
Ages 12 to 130 · All sexes · Updated Sep 18, 2026 · NCT06951867Cholate Clearance in Fontan and Heart Failure
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07009132Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
RecruitingPhase 3
Ages 18 to 99 · All sexes · Updated Sep 16, 2026 · NCT07037459From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.